Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature英文文献资料.docVIP

International Journal of Clinical Medicine, 2012, 3, 234-237 /10.4236/ijcm.2012.33047 Published Online May 2012 (http://www.SciRP.org/journal/ijcm) Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature Vallabhaneni Kalyan Chakravarthi, E. Aruna, Damera Naveen Chandra Rao, Diddi Ranga Rao Department of Pathology, Dr.PSIMS RF, Chinna Avutapalli, India. Email: kalyancv74@ Received January 5 , 2012; revised February 18 , 2012; accepted March 24 , 2012 th th th ABSTRACT Xanthoma of bone is a rare benign bone disorder. It radiologically presents as a lytic lesion, often with cortical expan- sion or disruption, mimics primary bone tumors and metastatic lesions. Histopathological study gives the definitive di- agnosis. Xanthoma of bilateral tibia in a normolipidemic patient is rare and not yet reported in literature. Here with we present one such rare case, with review of literature. Keywords: Xanthoma; Normolipidic; Tibia; Lytic Lesion 1. Introduction Xanthoma of bone is an exceedingly rare benign primary bone tumor. Intraosseous xanthomas are lytic, expansile lesions composed of lipid-laden histiocytes, [1] often seen in patients with hyperlipidemic conditions [2,3]. Xan- thomas are histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multi- nucleated giant cells. Occasionally, spindle cells are pre- sent, which has led investigators to include this lesion as a subset of benign fibrous histiocytoma (BFH) of bone [4]. One 45 years old lady who presented to our institu- tion was discovered to have an intraosseous xanthoma in both tibia in the absence of hyperlipidemia. The lesion showed abundant giant cells, mononuclear cells, foam Figure 1. X-ray of left leg showing fracture of both bones and an