Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys英文文献资料.docVIP

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Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys英文文献资料.doc

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Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys英文文献资料

HindawiPublishingCorporation JournalofOphthalmology Volume2010,ArticleID926192,5pages doi:10.1155/2010/926192 ResearchArticle BimatoprostEffectsonAqueousHumorDynamicsinMonkeys DavidF.Woodward, AchimH.-P.Krauss, andSivF.E.Nilsson 1 2 3 1 2 3 DepartmentofBiologicalSciences,Allergan,Inc.,Irvine,CA92612,USA Ophthiris,GlaxoSmithKline,KingofPrussia,PA,USA DivisionofDrugResearch,DepartmentofMedicalandHealthSciences,FacultyofHealthSciences, UniversityofLink¨oping,Link¨oping,Sweden CorrespondenceshouldbeaddressedtoDavidF.Woodward,woodwarddavid@ Received9July2009;Revised2December2009;Accepted28February2010 AcademicEditor:IanGrierson Copyright?2010DavidF.Woodwardetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Thee?ectsofbimatoprostonaqueoushumordynamicswerequanti?edinmonkeyeyes.Uveoscleralout?owwasmeasuredbythe anteriorchamberperfusionmethod,usingFITC-dextran.Totalout?owfacilitywasdeterminedbythetwo-levelconstantpressure method.Aqueous?owwasmeasuredwithascanningocular?uorophotometer.Uveoscleralout?owwas0.96± 0.19μLmin?1in ?1 vehicle-treatedeyesand1.37±0.27μLmin (n=6;P.05)ineyesthatreceivedbimatoprost0.01%b.i.d.×5days.Bimatoprost ?1 ?1 hadnoe?ectontotalout?owfacility,whichwas0.42± 0.05μLmin atbaselineand0.42± 0.04μLmin afterbimatoprost treatment.Bimatoprosthadnosigni?cante?ectonaqueoushumor?ow.Thisstudydemonstratesthatbimatoprostincreases uveoscleralout?owbutnottotalout?owfacilityoraqueoushumor?ow,indicatingthatitlowersintraocularpressureinocular normotensivemonkeysbyamechanismthatexclusivelyinvolvesuveoscleralout?ow. 1.Introduction wastoprovideadirectmeasurementofuveoscleralout?ow in primates, of a nonhuman variety. Total out?ow facility wasalsomeasureddirectlybythetwo-levelconstantpressure method.Forcompletion,aqueoushumor?owwasmeasured ?uorphotometrically. Bimatoprost (Lu