Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4Ce,Tb,Gd Nanocrystals英文文献资料.docVIP

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Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4Ce,Tb,Gd Nanocrystals英文文献资料.doc

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Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4Ce,Tb,Gd Nanocrystals英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2011,ArticleID531217,7pages doi:10.1155/2011/531217 ResearchArticle BimodalFluorescenceandMagneticResonanceImagingUsing Water-SolubleHexagonalNaYF4:Ce,Tb,GdNanocrystals FeiQi, ZhengBoSun, WenTingRen,1,2LiangBoLiang,1 1 3ZhiYongYang,1,2XiaoQiHuang,2 XueFengYu,1,3HongQuan,1 2 QiZhuWu, 2 HongYanZhu, 4 andQiYongGong 1 DepartmentofPhysics,KeyLaboratoryofArti?cialMicro-andNano-StructuresofMinistryofEducationandSchoolofPhysicsand Technology,WuhanUniversity,Wuhan430072,China 2 HuaxiMRResearchCenter(HMRRC),DepartmentofRadiology,WestChinaHospitalofSichuanUniversity, Chengdu610041,China 3 4 StateKeyLaboratoryofVirology,CollegeofLifeSciences,WuhanUniversity,Wuhan430072,China LaboratoryofStemCellBiology,StateKeyLaboratoryoftheBiotherapy,WestChinaHospitalofSichuanUniversity, Chengdu610041,China CorrespondenceshouldbeaddressedtoXueFengYu,yxf@andHongQuan,csp6606@ Received12July2011;Accepted13September2011 AcademicEditor:AnukornPhuruangrat Copyright?2011WenTingRenetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Thepresentstudyexploredthefeasibilityofusinghexagonal-phaseNaYF4:Ce,Tb,Gdnanocrystalsasbimodalprobesfor?uo- rescenceandmagneticresonance(MR)imaging.Usingafacileanduser-friendlystrategy,theNaYF4:Ce,Tb,Gdnanocrystalswere s synthesizedwithgoodwaterdispensability,highquantumyield(26%),anddecentMRT1relaxivity(r1 =2.87mM?1 ?1 ).The NaYF4:Ce,Tb,GdNCsconjugatedbyfolicacidpresentedgreate?ciencyin?uorescenceimagingofC6gliomacellsinvitro .Mean- while,ininvivoMRexperimentsonrats,theNaYF4:Ce,Tb,GdNCsalsosigni?cantlyincreasedT1signalintheliver,spleen,and kidneyevenwithalowprobedose.TheproposedNaYF4:Ce,Tb,Gdnanoprobesholdpromiseforsimultaneousbimodal?uores- cenceandMRbioimaging. 1.Introduction tionshavebeenexploitedsuchasbiologicalmarking