Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles英文文献资料.docVIP

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Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles英文文献资料.doc

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Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles英文文献资料

HindawiPublishingCorporation InternationalJournalofPolymerScience Volume2010,ArticleID436178,9pages doi:10.1155/2010/436178 ResearchArticle BimodalPorousScaffoldsbySequentialElectrospinningof Poly(glycolicacid)withSucroseParticles B.Wulkersdorfer, 1 K.K.Kao,1,2V.G.Agopian,1,2A.Ahn,1J.C.Dunn, 2,3 B.M.Wu,2,3andM.Stelzner 1,2 1 2 3 DepartmentofSurgery,VAGreaterLosAngelesHealthCareSystem,LosAngeles,CA90073,USA DepartmentofSurgery,UniversityofCaliforniaatLosAngeles,LosAngeles,CA90095,USA DepartmentofBioengineering,UniversityofCaliforniaatLosAngeles,LosAngeles,CA90095,USA CorrespondenceshouldbeaddressedtoM.Stelzner,matthias.stelzner@ Received20November2009;Revised20January2010;Accepted20January2010 AcademicEditor:ShanfengWang Copyright?2010B.Wulkersdorferetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Electrospinningisamethodtoproduce?ne,biopolymermeshwithathree-dimensionalarchitecturethatmimicsnativeextra- cellularmatrix.Duetothesmall?berdiametercreatedinthisprocess,conventionalelectrospunsca?oldshaveporesizessmaller thanthediameterofmostcells.Thesesca?oldshavelimitedapplicationintissueengineeringduetopoorcellpenetration.We developedahybridelectrospinning/particulateleachingtechniquetocreatesca?oldswithincreasedporosityandimprovedcellular ingrowth.Poly(glycolicacid)(PGA)andasucrose-ethanolsuspensionwereelectrospuninequal,alternatingsequencesatintervals ofone,two,andtenminuteseach.Thesca?oldsrevealed?bermeshwithmicroporesof10μmanduniformlydistributedsucrose particles.Particulateleachingofsucrosefromtheone-ortwo-minutesca?oldsrevealedhoneycombstructureswithinterconnected macroporesbetween50and250μm.Sucroseleachingfromtheten-minutesca?oldsresultedinlaminatedstructureswithisolated macroporesbetween200and350μm.Macroporesizewasdirectlyproportionaltothedurationofthesucrosespinninginterval. After24hoursofcellculture,conv