Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis 50%英文文献资料.docVIP

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Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis 50%英文文献资料.doc

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Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis 50%英文文献资料

HindawiPublishingCorporation InternationalJournalofVascularMedicine Volume2012,ArticleID579531,8pages doi:10.1155/2012/579531 ClinicalStudy CarotidVelocitiesDetermineCerebralBloodFlowDe?citsin ElderlyMenwithCarotidStenosis50% ArkadiuszSiennicki-Lantz, PerWollmer, andS¨olveElmst?ahl 1 2 1 1 DivisionofGeriatricMedicine,DepartmentofHealthSciences,SkaneUniversityHospitalinMalm¨o,LundUniversity, 20502Malm¨o,Sweden 2 UnitofClinicalPhysiologyandNuclearMedicine,DepartmentofClinicalSciences,SkaneUniversityHospitalinMalm¨o, LundUniversity,20502Malm¨o,Sweden CorrespondenceshouldbeaddressedtoArkadiuszSiennicki-Lantz,arkadiusz.siennicki-lantz@med.lu.se Received1October2011;Revised29March2012;Accepted17April2012 AcademicEditor:MarioZuccarello Copyright?2012ArkadiuszSiennicki-Lantzetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Toexamineifmildcarotidstenosiscorrelateswithsilentvascularbrainchanges,westudiedaprospectivepopulation-basedcohort “Menbornin1914.”Datafromfollowupsatages68and81,havebeenused.Carotidultrasoundwasperformedatage81,and cerebralblood?ow(CBF)wasmeasuredwithSPECTatage82.Outof123stroke-freepatients,carotidstenosis50%wasobserved in94%intherightand89%intheleftinternalcarotidarteries(ICAs).Inthesesubjects,PeakSystolicVelocitiesinICAcorrelated negativelywithCBFinamajorityofseveralbrainareas,especiallyinmesialtemporalarea.Resultswerelimitedtonormotensive untiltheirseventies,whodevelopedlate-onsethypertensionwithasubsequentbloodpressure,pulsepressure,andankle-brachial indexgrowth.Elderlywithasymptomaticcarotidstenosis50%andpeaksystolicvelocitiesinICA0.7–1.3m/s,shouldbeo?ered anintensi?edpharmacotherapytopreventstrokeorsilentcerebrovascularevents. 1.Introduction themildcarotidstenosisisresponsiblefor,orcorrelateswith silentvascularbrainchanges. Stroke risk in patients with symptoma