Cerebral Blood Flow Measurement in the Assessment of Post-Traumatic Cerebral Contusions英文文献资料.docVIP

Open Journal of Radiology, 2011, 1, 21-27 21 doi:10.4236/ojrad.2011.12004 Published Online December 2011 (http://www.SciRP.org/journal/ojrad) Cerebral Blood Flow Measurement in the Assessment of Post-Traumatic Cerebral Contusions P. Pifarré , G. Cuberas , B. Benejam , L. Frascherri , J. Sahuquillo , J. Castell-Conesa 1 1 2 1 2 1 Nuclear Medicine Department, Hospital Universitaria de la Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain 1 2 Neurosurgery Department, Hospital Universitari de la Vall d’Hebron, Barcelona, Spain Radiology Department, Hospital Universitari de la Vall d’Hebron, Barcelona, Spain E-mail: paloma.pifarre@crccorp.es 3 Received September 22, 2011; revised October 20, 2011; accepted November 8, 2011 Abstract Brain trauma (BT) is extremely common in the Western society, and has been identified as the main cause of death and disability in the under-40 age group. Many aspects of the pathophysiological mechanisms involved and the effect of changes in cerebral metabolism are unclear. The aim of this study was to establish the rela- tionship between anatomical changes and deranged cerebral perfusion in patients with cerebral contusions, using Computed Tomography (CT) and Single Proton Emission Computed Tomography (SPECT). Twenty- two (22) patients who had suffered BT were recruited. All patients underwent SPECT and CT head scans on the same day. 18 were men. Patient average age was 45.6. Patients were assessed using the Glasgow scale (average 10.6). Cause of trauma included traffic accidents (9 patients) and falls (13 patients). A 4-slice spiral CT scan was performed. For each contusion, areas of bleeding, edema, and healthy perilesional tissue were distinguished. SPECT was performed with 20 mCi of 99 mTcECD using a dual-head gamma c