Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats英文文献资料.docVIP

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Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats英文文献资料.doc

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Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofNephrology Volume2011,ArticleID142896,5pages doi:10.4061/2011/142896 ResearchArticle CerebralEpiphysealProteinsandMelatoninModulate theHepaticandRenalAntioxidantDefenseofRats P.Subramaian, D.WarrenSpence, VijayK.Bharti,1,2R.S.Srivastava,1 3 4 andGregoryM.Brown 6,7 S.R.Pandi-Perumal, 5 1 NeurophysiologyLaboratory,DivisionofPhysiologyandClimatology,IndianVeterinaryResearchInstitute(IVRI), Izatnagar243122,India 2 NutritionandToxicologyLaboratory,DefenceInstituteofHighAltitudeResearch(DIHAR), DefenceResearchandDevelopmentOrganization(DRDO),MinistryofDefence,C/o-56APO,Leh194101,India DepartmentofBiochemistryandBiotechnology,FacultyofSciences,AnnamalaiUniversity,Annamalainagar608002,India 323BrockAve,Toronto,ON,CanadaM6K2M6 SomnogenInc.,CollegeStreet,Toronto,ON,CanadaM6H1C5 DepartmentofPsychiatry,UniversityofToronto,100BronteRoad,Unit422,Oakville,ON,CanadaL6L6L5 CentreforAddictionandMentalHealth,250CollegeStreet,Toronto,ON,CanadaM5T1R8 3 4 5 6 7 CorrespondenceshouldbeaddressedtoVijayK.Bharti,vijaykbharti@redi? Received17January2011;Revised24March2011;Accepted30March2011 AcademicEditor:NuketBavbek Copyright?2011VijayK.Bhartietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Thecerebral epiphysis(pinealgland)secretsmelatoninandnumber ofotherproteinsandpeptides. Itwasthushypothesized thatantioxidantpropertiesofepiphysealproteinsandmelatonincouldpotentiallybene?tfromexogenoustherapies.Inviewof thetherapeuticpotentialoftheseproteins,thepresentexperimentwasconductedtoinvestigatethee?ectofbu?aloepiphyseal proteins(BEP,at100μg/kgBW,i.p.)andmelatonin(MEL,at10mg/kgBW,i.p)onchangesinhepaticandrenalantioxidant enzymesofadultfemaleWistarrats.Bu?aloepiphysealproteinssigni?cantly(P.05)increasedhepaticlipidperoxidation(LPO), superoxidedismutase(SOD),glutat