靛红去氢表雄酮的抗癌活性9Discovery of novel isatin–dehydroepiandrosterone.pdfVIP

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靛红去氢表雄酮的抗癌活性9Discovery of novel isatin–dehydroepiandrosterone.pdf

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靛红去氢表雄酮的抗癌活性9Discovery of novel isatin–dehydroepiandrosterone

Bioorganic Medicinal Chemistry Letters 25 (2015) 4628–4631 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry Letters journal homepage: /locate/bmcl Discovery of novel isatin–dehydroepiandrosterone conjugates as potential anticancer agents ⇑,y y Shaoyong Ke , Liqiao Shi , Ziwen Yang National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, People’s Republic of China a r t i c l e i n f o a b s t r a c t Article history: A series of isatin–dehydroepiandrosterone hybrids were synthesised via a convenient condensation Received 10 July 2015 procedure, and which were evaluated for their potential anticancer activities. The preliminary assays Revised 4 August 2015 indicated that some of the newly obtained compounds exhibited good antitumor activities against Accepted 14 August 2015 human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), melanoma (A875) and Available online 20 August 2015 5-ﬂuorouracil-resistant human hepatocellular carcinoma (BEL-7402/5-FU) cell lines compared with 5-ﬂuorouracil (5-FU), which might be considered as promising lead scaffold for further design and Keywords: synthesis of highly potential anticancer agents. Isatin