Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus 外文参考文献.docVIP

下载本文档

5
0
约6.18万字
约 18页
2017-05-10 发布于上海
举报
版权申诉

Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus 外文参考文献.doc

1、本文档共18页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus 外文参考文献

HindawiPublishingCorporation NeuralPlasticity Volume2011,ArticleID859359,17pages doi:10.1155/2011/859359 ResearchArticle Deafferentation-InducedRedistributionofMMP-2, butNotofMMP-9,DependsontheEmergenceofGAP-43Positive AxonsintheAdultRatCochlearNucleus MichaelaFredrichandRobert-BenjaminIlling NeurobiologicalResearchLaboratory,DepartmentofOtorhinolaryngology,UniversityofFreiburg,Killianst.5, D-79106Freiburg,Germany CorrespondenceshouldbeaddressedtoRobert-BenjaminIlling,robert.illing@uniklinik-freiburg.de Received29April2011;Accepted17August2011 AcademicEditor:SarahMcFarlane Copyright?2011M.FredrichandR.-B.Illing.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. ThematrixmetalloproteinasesMMP-9andMMP-2,majormodulatorsoftheextracellularmatrix(ECM),werechangedinamount and distribution in the rat anteroventral cochlear nucleus (AVCN) following its sensory dea?erentation by cochlear ablation. To determine what causal relationships exist between the redistribution of MMP-9 and MMP-2 and dea?erentation-induced reinnervation,kainicacidwasstereotaxicallyinjectedintotheventralnucleusofthetrapezoidbody(VNTB)priortocochlear ablation,killingcellsthatdeliverthegrowthassociatedprotein43(GAP-43)intoAVCN.Dea?erentation-inducedchangesinthe patternofMMP-9stainingremaineduna?ectedbyVNTBlesions.Bycontrast,changesinthedistributionofMMP-2normally evokedbysensorydea?erentationwerereversedifGAP-43positiveaxonswerepreventedtogrowinAVCN.Inconclusion,GAP- 43-containingaxonsemerginginAVCNaftercochlearablationseemtobecausalforthemaintenanceofMMP-2-mediatedECM remodeling. 1.Introduction presynaptic terminals growing into the anteroventral CN (AVCN)[10,11].These?bersoriginatefromneuronsofthe medial olivocochlear (MOC) system arising in the ventral nucleusofthetrapezoidbody(VNTB),arhombencephalic regioncharacterizedbyconspicuouslylargecholinergicneu- rons[10,12]