多发性硬化的MRI诊断2011223.ppt

Overview Multiple sclerosis (MS) is a central nervous system demyelinating diseases . 多发性硬化（multiple sclerosis,MS）是一种中枢神经系统脱髓鞘疾病 Young, middle-aged common . 青、中年多见 Widely disseminated lesions of clinical features, course of disease recurrence often alleviate symptoms of nervous system damage . 临床特点是病灶播散广泛，病程中常有缓解复发的神经系统损害症状 Disease lesions in the brain or spinal cord . 该病的病变位于脑部或脊髓 Generated in the central nervous system because the sizes of the symptoms caused massive loss of myelin sheath 因为在中枢神经系统中产生大小不一的块状髓鞘脱失而产生症状 The so-called hardenedrefers to the area because of these demyelination produced during tissue repair scar tissue and hardened 所谓“硬化”指的是这些髓鞘脱失的区域因为组织修复的过程中产生的疤痕组织而变硬 These lumps may be several, as time progressed, new lumps may also appear, so called multiple . 这些硬块可能会有好几个，随着时间的进展，新的硬块也可能出现，所以称 “多发性”。 Cause of disease Virus infection: such as herpes virus (chickenpox, simple, simple chicken pox), measles virus, 病毒感染：如疱疹病毒（水痘、单纯、水痘单纯）、麻疹病毒等 Autoimmune response: that is mediated by T cells in autoimmune diseases. 自身免疫反应：认为是由T细胞所介导的自身免疫性疾病。 Genetic factors: There is a certain degree of familial aggregation tendency 遗传因素：有一定程度的家族聚集倾向 Environmental factors: climate is cold-related 环境因素：与气候是否寒冷有关 Clinical classification relapsing-remitting : The most common 复发——缓解型：最常见 prinmary-progressive ： Advances in remission after the onset of increased 复发渐进型 ：发病后病情缓解进展加重 seconday-progressive ： Progressive worsening of symptoms in patients 继发进展性：患者出现渐进性症状恶化 progressive-relapsing ： Rare 进展复发型：少见 Clinical manifestations Common symptoms of a certain parts of the muscle stiffness, fatigue, loss of control, limbs abnormal fatigue, difficulty walking 常见的症状有一定部位的肌肉僵硬，乏力、丧失控制能力，四肢异常疲劳、行走困难 Each will disappear after the onset of symptoms. In this way one after another, or continue to deteriorate, and finally make swallowing difficult. Disabled and bedridden 每个症状出现后又会消失。就这样一个接一个的相继发生，或继续恶化，最后可使患者吞咽困难，致残及卧床不起 Treatment No specific drug treatment of this disease