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60 kD Ro and nRNP A Frequently Initiate Human Lupus Autoimmunity 英文参考文献
60kDRoandnRNPAFrequentlyInitiateHumanLupus
Autoimmunity
LatishaD.Heinlen1,2,3,MicahT.McClain1,LaurenL.Ritterhouse1,2,3,BenjaminF.Bruner1,ColinC.
Edgerton4,MichaelP.Keith5,JudithA.James1,2,3,JohnB.Harley2,3,6,7
*
1DepartmentofClinicalImmunology,OklahomaMedicalResearchFoundation,OklahomaCity,Oklahoma,UnitedStatesofAmerica,2DepartmentofInternalMedicine,
UniversityofOklahomaHealthSciencesCenter,OklahomaCity,Oklahoma,UnitedStatesofAmerica,3DepartmentofPathology,UniversityofOklahomaHealthSciences
Center,OklahomaCity,Oklahoma,UnitedStatesofAmerica,4WalterReedArmyMedicalCenter,Washington,DistrictofColumbia,UnitedStatesofAmerica,5National
NavalMedicalCenter,Bethesda,Maryland,UnitedStatesofAmerica,6UnitedStatesDepartmentofVeteransAffairs,OklahomaCity,Oklahoma,UnitedStatesofAmerica,
7DepartmentofArthritisandImmunology,OklahomaMedicalResearchFoundation,OklahomaCity,Oklahoma,UnitedStatesofAmerica
Abstract
Systemic lupus erythematosus (SLE) is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature
among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected
beforetheonsetofSLEandwhileintheUnitedStatesmilitarywereevaluatedforearlypre-clinicalserologicevents.Thefirst
availablepositiveserumsamplefrequentlyalreadycontainedmultipleautoantibodyspecificities(65%).However,in34SLE
patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single
autoantigen, most commonly 60kD Ro (29%), nRNP A (24%), anti-phospholipids (18%) or rheumatoid factor (15%). We
identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples
available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70K in 96% of the patients who had both
autoantibodiesatdiagnosis.Anti-60kDRoantibodiesappearedbeforeorsimultaneouslywithanti-La(98%)oranti-52kD
Ro(95%).TheautoantibodyresponseinSLEpatientsbeginssimply,oftenbindingasingles
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