A Dynamical Model of Genetic Networks for Cell Differentiation 英文参考文献.docVIP

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A Dynamical Model of Genetic Networks for Cell Differentiation 英文参考文献.doc

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A Dynamical Model of Genetic Networks for Cell Differentiation 英文参考文献

ADynamicalModelofGeneticNetworksforCell Differentiation MarcoVillani1,2,AlessiaBarbieri1,RobertoSerra1,2* 1ModellingandSimulationLaboratory,DepartmentofCommunicationsandEconomics,UniversityofModenaandReggioEmilia,ReggioEmilia,Italy,2EuropeanCentre forLivingTechnology,Venice,Italy Abstract Amathematicalmodelisproposedwhichisabletodescribethemostimportantfeaturesofcelldifferentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiationisdescribedhereasanemergentpropertyofagenericmodeloftheunderlyinggeneregulatorynetwork, anditcanthereforebeappliedtoavarietyofdifferentorganisms.Themodelpointstoapeculiarroleofcellularnoisein differentiationandleadstonontrivialpredictionswhichcouldbesubjecttoexperimentaltesting.Moreover,asinglemodel provesabletodescribeseveraldifferentphenomenaobservedinvariousdifferentiationprocesses. Citation: Villani M, Barbieri A, Serra R (2011) A Dynamical Model of Genetic Networks for Cell Differentiation. PLoS ONE 6(3): e17703. doi:10.1371/ journal.pone.0017703 Editor:OlivierGires,Ludwig-MaximiliansUniversity,Germany ReceivedDecember6,2010;AcceptedFebruary8,2011;PublishedMarch18,2011 Copyright: ? 2011 Serra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkhasbeensupportedinpartbytheItalianMiurProjectMITICA(FISRnr.2982/Ric)andbytheDICEprojectoftheFondazionediVenezia.The fundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:roberto.serra@unimore.it Introduction differentiation can come back to a previous stage, under the actionofappropriatesignals[5][6]; A major challenge in complex systems biology is that of providing a general