A Phenomenological Theory of Spatially Structured Local Synaptic Connectivity 英文参考文献.docVIP

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A Phenomenological Theory of Spatially Structured Local Synaptic Connectivity 英文参考文献.doc

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A Phenomenological Theory of Spatially Structured Local Synaptic Connectivity 英文参考文献

APhenomenologicalTheoryofSpatially StructuredLocalSynapticConnectivity Bagrat Amirikian Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, Minnesota, United States of America, and Department of Neuroscience, University of Minnesota, Minneapolis,Minnesota,UnitedStatesofAmerica The structure of local synaptic circuits is the key to understanding cortical function and how neuronal functional modules such as cortical columns are formed. The central problem in deciphering cortical microcircuits is the quantificationofsynapticconnectivitybetweenneuronpairs.Ipresentatheoreticalmodelthataccountsfortheaxon and dendrite morphologies of pre- and postsynaptic cells and provides the average number of synaptic contacts formedbetweenthemasafunctionoftheirrelativelocationsinthree-dimensionalspace.Animportantaspectofthe currentapproachistherepresentationofacomplexstructureofanaxonal/dendriticarborasasuperpositionofbasic structures—synaptic clouds. Each cloud has three structural parameters that can be directly estimated from two- dimensional drawings of the underlying arbor. Using empirical data available in literature, I applied this theory to threemorphologicallydifferenttypesofcellpairs.Ifoundthat,withinawiderangeofcellseparations,thetheoryisin verygoodagreementwithempiricaldataon(i)axonal–dendriticcontactsofpyramidalcellsand(ii)somaticsynapses formed by the axons of inhibitory interneurons. Since for many types of neurons plane arborization drawings are availablefromliterature,thistheorycanprovideapracticalmeansforquantitativelyderivinglocalsynapticcircuits basedontheactualobserveddensitiesofspecifictypesofneuronsandtheirmorphologies.Itcanalsohavesignificant implicationsforcomputationalmodelsofcorticalnetworksbymakingitpossibletowireupsimulatedneuralnetworks inarealisticfashion. Citation:AmirikianB(2005)Aphenomenologicaltheoryofspatiallystructuredlocalsynapticconnectivity.PLoSCompBiol1(1):e11. To form a synaptic contact it is necessary that the presynaptic