Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1 英文参考文献.docVIP

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Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1 英文参考文献.doc

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Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1 英文参考文献

AcuteMultipleOrganFailureinAdultMiceDeletedfor theDevelopmentalRegulatorWt1 You-YingChau1,DavidBrownstein2,HeidiMjoseng3,Wen-ChinLee4,NatalijaBuza-Vidas5 ,Claus Nerlov5,StenEirikJacobsen6,PaulPerry1,RachelBerry1,AnnaThornburn1,DavidSexton1,NikMorton7, PeterHohenstein1,ElisabethFreyer1,KaySamuel8,Robvan’tHof9,NicholasHastie1* 1MedicalResearchCouncilHumanGeneticsUnitandtheInstituteofGeneticsandMolecularMedicine,WesternGeneralHospital,Edinburgh,UnitedKingdom,2Queen’s Medical Research Institute, Edinburgh, United Kingdom, 3Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom, 4Division of Nephrology,DepartmentofInternalMedicine,KaohsiungChangGungMemorialHospitalandChangGungUniversityCollegeofMedicine,Kaohsiung,Taiwan,5Institute ofStemCellResearch,MedicalResearchCouncilCentreforRegenerativeMedicine,Edinburgh,UnitedKingdom,6TheWeatherallInstituteofMolecularMedicine,John RadcliffeHospital,UniversityofOxford, Oxford,United Kingdom, 7Centrefor Cardiovascular Science,UniversityofEdinburgh,Edinburgh,United Kingdom, 8Scottish National Blood Transfusion Service, Centre for Regenerative Medicine, Edinburgh, United Kingdom, 9Molecular Medicine Centre and the Institute of Genetics and MolecularMedicine,WesternGeneralHospital,Edinburgh,UnitedKingdom Abstract There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governingfoetaldevelopment.MicedeletedfortheWilms’tumourgene,Wt1,lackkidneys,gonads,andspleenanddieat mid-gestation due to defective coronary vasculature. Wt1 is vital for maintaining the mesenchymal–epithelial balance in these tissues and is required for the epithelial-to-mesenchyme transition (EMT) that generates coronary vascular progenitors.AlthoughWt1isonlyexpressedinrarecellpopulationsinadultsincludingglomerularpodocytes,1%ofbone marrowcells,andmesothelium,wehypothesisedthatthismightbeimportantforhomeostasisofadulttissues;hence,we deleted the gene ubiquitously in young a