Adipokine Hormones and Hand Osteoarthritis Radiographic Severity and Pain 英文参考文献.docVIP

下载本文档

4
0
约 5页
2017-05-11 发布于上海
举报
版权申诉

Adipokine Hormones and Hand Osteoarthritis Radiographic Severity and Pain 英文参考文献.doc

1、本文档共5页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Adipokine Hormones and Hand Osteoarthritis Radiographic Severity and Pain 英文参考文献

AdipokineHormonesandHandOsteoarthritis: RadiographicSeverityandPain MeiMassengale1,6,8*,BingLu1,6,JohnJ.Pan7,JeffreyN.Katz1,3,4,5,6,DanielH.Solomon1,2,6 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 2Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital/Harvard Medical School, Boston, Massachusetts, United States of America, 3DepartmentofOrthopedicSurgery,BrighamandWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica,4OrthopaedicandArthritisCenterforOutcomes Research,Brigham and Women’s Hospital, Boston, Massachusetts,United States ofAmerica, 5Department ofEpidemiology, Harvard School of Public Health, Boston, Massachusetts,UnitedStatesofAmerica,6HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,7DivisionofMusculoskeletalRadiology,Department of Radiology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 8Center for Regenerative Medicine, Massachusetts General Hospital, Boston,Massachusetts,UnitedStatesofAmerica Abstract Introduction:Obesity’sassociationwithhandosteoarthritiscannotbefullyexplainedbymechanicalloading.Weexamined therelationshipbetweenadipokinesandradiographichandosteoarthritisseverityandpain. Methods:Inapilotstudyof44handosteoarthritispatients(39womenand5men),serumadipokineconcentrationsand handx-rayKallman-scoreswereanalyzedusinglinearregressionmodels.Secondaryanalysesexaminedcorrelatesofhand pain. Results:Thecohorthadameanageof63.5yearsforwomenand72.6formen;mean(standarddeviation)Kallman-scores were43.3(17.4)forwomenand46.2(10.8)formen.Meanbody-mass-indexwas30kg/m2forwomenandmen.Meanleptin concentrationwas32.2ng/ml(women)and18.5ng/ml(men);meanadiponectin-totalwas7.9ng/ml(women)and5.3ng/ ml(men);meanresistinwas7.3ng/ml(women)and9.4ng/ml(men).NoassociationwasfoundbetweenKallman-scores and adipokine concentrations (R2=0.00–0.04 unadjusted analysis, all p-values.0.22). Secondary analyse