Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease 英文参考文献.docVIP

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Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease 英文参考文献.doc

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Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease 英文参考文献

AgrochemicalsagainstMalaria,SleepingSickness, LeishmaniasisandChagasDisease MatthiasWitschel1*,MatthiasRottmann2,3,MarcelKaiser2,3,RetoBrun2,3 * 1BASFSE,GlobalResearchHerbicides,Ludwigshafen,Germany,2SwissTropicalandPublicHealthInstitute,Basel,Switzerland,3UniversityofBasel,Basel,Switzerland Abstract Intropicalregions,protozoanparasitescancauseseverediseaseswithmalaria,leishmaniasis,sleepingsickness,andChagas diseasestandingintheforefront.Manyofthedrugscurrentlybeingusedtotreatthesediseaseshavebeendevelopedmore than 50 years ago and can cause severe adverse effects. Above all, resistance to existing drugs is widespread and has becomeaseriousproblemthreateningthesuccessofcontrolmeasures.Inordertoidentifynewantiprotozoalagents,more than600commercialagrochemicalshavebeentestedonthepathogenscausingtheabovementioneddiseases.Forallof thepathogens,compoundswereidentifiedwithsimilarorevenhigheractivitiesthanthecurrentlyuseddrugsinappliedin vitro assays. Furthermore, in vivo activity was observed for the fungicide/oomyceticide azoxystrobin, and the insecticide hydramethylnoninthePlasmodiumbergheimousemodel,andfortheoomyceticidezoxamideintheTrypanosomabrucei rhodesienseSTIB900mousemodel,respectively. Citation:WitschelM,RottmannM,KaiserM,BrunR(2012)AgrochemicalsagainstMalaria,SleepingSickness,LeishmaniasisandChagasDisease.PLoSNeglTrop Dis6(10):e1805.doi:10.1371/journal.pntd.0001805 Editor:MichaelP.Pollastri,NortheasternUniversity,UnitedStatesofAmerica ReceivedMay31,2012;AcceptedJuly18,2012;PublishedOctober25,2012 Copyright: ? 2012 Witschel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThestudyhasbeenfinancedbyagrantbyBASF-SE.ThecorrespondingauthorisanemployeeofBASF-SE.BASF-SEhadnoroleinstudydesignand datacollection.Analysis,decisiontopublish,orpreparationofthemanuscripthasbeendonejointlyb