Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis 英文参考文献.docVIP

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Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis 英文参考文献.doc

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Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis 英文参考文献

AkirinLinksTwist-RegulatedTranscriptionwiththe BrahmaChromatinRemodelingComplexduring Embryogenesis ScottJ.Nowak1¤a,HitoshiAihara2¤b,KatieGonzalez3¤c,YutakaNibu2,3,MaryK.Baylies1,3 * 1PrograminDevelopmentalBiology,SloanKetteringInstitute,NewYork,NewYork,UnitedStatesofAmerica,2CellandDevelopmentalBiology,WeillCornellMedical College,NewYork,NewYork,UnitedStatesofAmerica,3WeillCornellGraduateSchoolofBiomedicalSciences,CornellUniversity,NewYork,NewYork,UnitedStatesof America Abstract Theactivitiesofdevelopmentallycriticaltranscriptionfactorsareregulatedviainteractionswithcofactors.Suchinteractions influencetranscriptionfactoractivityeitherdirectlythroughprotein–proteininteractionsorindirectlybyalteringthelocal chromatinenvironment.Usingayeastdouble-interactionscreen,weidentifiedahighlyconservednuclearprotein,Akirin,as anovelcofactorofthekeyDrosophilamelanogastermesodermandmuscletranscriptionfactorTwist.WefindthatAkirin interacts genetically and physically with Twist to facilitate expression of some, but not all, Twist-regulated genes during embryonicmyogenesis.akirinmutantembryoshavemuscledefectsconsistentwithalteredregulationofasubsetofTwist- regulatedgenes.Toregulatetranscription,AkirincolocalizesandgeneticallyinteractswithsubunitsoftheBrahmaSWI/SNF- classchromatinremodelingcomplex.Ourresultssuggestthat,mechanistically,Akirinmediatesanovelconnectionbetween Twist and a chromatin remodeling complex to facilitate changes in the chromatin environment, leading to the optimal expression of some Twist-regulated genes during Drosophila myogenesis. We propose that this Akirin-mediated link between transcription factors and the Brahma complex represents a novel paradigm for providing tissue and target specificityfortranscriptionfactorinteractionswiththechromatinremodelingmachinery. Citation:NowakSJ,AiharaH,GonzalezK,NibuY,BayliesMK(2012)AkirinLinksTwist-RegulatedTranscriptionwiththeBrahmaChromatinRemodelingComplex duringEmbryogenesis.PLoSGenet8(3):e1002547.doi:10.1371/journal