Alcohol Intake and Blood Pressure A Systematic Review Implementing a Mendelian Randomization Approach 英文参考文献.docVIP

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Alcohol Intake and Blood Pressure A Systematic Review Implementing a Mendelian Randomization Approach 英文参考文献.doc

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Alcohol Intake and Blood Pressure A Systematic Review Implementing a Mendelian Randomization Approach 英文参考文献

o PL SMEDICINE AlcoholIntakeandBloodPressure:ASystematic ReviewImplementingaMendelian RandomizationApproach Lina Chen1,George Davey Smith2,Roger M.Harbord1,Sarah J.Lewis1* 1 Department of Social Medicine, University of Bristol, Bristol, United Kingdom, 2 Medical Research Council Centre for Causal Analyses in Translational Epidemiology, UniversityofBristol,Bristol,UnitedKingdom Funding:LCisinreceiptofan overseasresearchstudentshipand SJLisfundedbytheHigher ABSTRACT EducationFundingCouncilfor England.GDS’sworkinthisareais supportedbytheMRCCentrefor CausalAnalysesinTranslational Epidemiology.Nofurtherfunding wassoughtforthiswork.The fundershadnoroleinstudydesign, datacollectionandanalysis,decision topublish,orpreparationofthe manuscript Background Alcohol has been reported to be a common and modifiable risk factor for hypertension. However, observational studies are subject to confounding by other behavioural and sociodemographic factors, while clinical trials are difficult to implement and have limited follow-up time. Mendelian randomization can provide robust evidence on the nature of this association by use of a common polymorphism in aldehyde dehydrogenase 2 (ALDH2) as a surrogate for measuring alcohol consumption. ALDH2 encodes a major enzyme involved in alcohol metabolism. Individuals homozygous for the null variant (*2*2) experience adverse symptomswhendrinkingalcoholandconsequentlydrinkconsiderablylessalcoholthanwild- type homozygotes (*1*1) or heterozygotes. We hypothesise that this polymorphism may influencetheriskofhypertensionbyaffectingalcoholdrinkingbehaviour. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. AcademicEditor:CosettaMinelli, ImperialCollegeLondon,United Kingdom MethodsandFindings Citation:ChenL,DaveySmithG, HarbordR,LewisSJ(2008)Alcohol andbloodpressure:Asystematic reviewimplementingamendelian randomizationapproach.PLoSMed 5(3):e52.doi:10.1371/journal.pmed. 0050052 Wecarriedoutfixedeffectmeta-analysesoftheALDH2ge