Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimers Disease 英文参考文献.docVIP
- 1、本文档共13页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimers Disease 英文参考文献
AllopregnanolonePromotesRegenerationandReduces
b-AmyloidBurdeninaPreclinicalModelofAlzheimer’s
Disease
ShuhuaChen1,JunMingWang2,RonaldW.Irwin1,JiaYao1,LifeiLiu3,RobertaDiazBrinton1,3*
1Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America,
2Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 3Neuroscience Program, University of Southern
California,LosAngeles,California,UnitedStatesofAmerica
Abstract
Previously,wedemonstratedthatallopregnanolone(APa)promotedproliferationofrodentandhumanneuralprogenitor
cellsinvitro.Further,wedemonstratedthatAPapromotedneurogenesisinthehippocampalsubgranularzone(SGZ)and
reversedlearningandmemorydeficitsinthemaletripletransgenicmousemodelofAlzheimer’s(3xTgAD).Inthecurrent
study, we determined the efficacy of APa to promote the survival of newly generated neural cells while simultaneously
reducing Alzheimer’s disease (AD) pathology in the 3xTgAD male mouse model. Comparative analyses between three
different APa treatment regimens indicated that APa administered 1/week for 6 months was maximally efficacious for
simultaneouspromotionofneurogenesisandsurvivalofnewlygeneratedcellsandreductionofADpathology.Wefurther
investigated the efficacy of APa to impact Ab burden. Treatment was initiated either prior to or post intraneuronal Ab
accumulation. Results indicated that APa administered 1/week for 6 months significantly increased survival of newly
generatedneuronsandsimultaneouslyreducedAbpathologywithgreatestefficacyinthepre-pathologytreatmentgroup.
APa significantly reduced Ab generation in hippocampus, cortex, and amygdala, which was paralleled by decreased
expressionofAb-binding-alcohol-dehydrogenase.Inaddition,APasignificantlyreducedmicrogliaactivationasindicatedby
reducedexpressionofOX42whileincreasingCNPase,anoligodendrocytemyelinmarker.Mechanisticanalysesindicated
th
您可能关注的文档
- Air Bubble Contact with Endothelial Cells Causes a Calcium-Independent Loss in Mitochondrial Membrane Potential 英文参考文献.doc
- Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis 英文参考文献.doc
- Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition 英文参考文献.doc
- Airway and Esophageal Stenting in Patients with Advanced Esophageal Cancer and Pulmonary Involvement 英文参考文献.doc
- Akt Regulates IL-10 Mediated Suppression of TNFα-Induced Cardiomyocyte Apoptosis by Upregulating Stat3 Phosphorylation 英文参考文献.doc
- Alanine Aminotransferase Decreases with Age The Rancho Bernardo Study 英文参考文献.doc
- Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation 英文参考文献.doc
- Akt1 Intramitochondrial Cycling Is a Crucial Step in the Redox Modulation of Cell Cycle Progression 英文参考文献.doc
- Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway 英文参考文献.doc
- Akt1 Is Essential for Postnatal Mammary Gland Development, Function, and the Expression of Btn1a1 英文参考文献.doc
- GB/T 39560.10-2024电子电气产品中某些物质的测定 第10部分:气相色谱-质谱法(GC-MS)测定聚合物和电子件中的多环芳烃(PAHs).pdf
- 中国国家标准 GB/T 39560.10-2024电子电气产品中某些物质的测定 第10部分:气相色谱-质谱法(GC-MS)测定聚合物和电子件中的多环芳烃(PAHs).pdf
- 《GB/T 39560.10-2024电子电气产品中某些物质的测定 第10部分:气相色谱-质谱法(GC-MS)测定聚合物和电子件中的多环芳烃(PAHs)》.pdf
- GB/T 39560.302-2024电子电气产品中某些物质的测定 第3-2部分:燃烧-离子色谱法(C-IC)筛选聚合物和电子件中的氟、氯和溴.pdf
- 中国国家标准 GB/T 39560.2-2024电子电气产品中某些物质的测定 第2部分:拆解、拆分和机械制样.pdf
- 中国国家标准 GB/T 39560.302-2024电子电气产品中某些物质的测定 第3-2部分:燃烧-离子色谱法(C-IC)筛选聚合物和电子件中的氟、氯和溴.pdf
- GB/T 39560.2-2024电子电气产品中某些物质的测定 第2部分:拆解、拆分和机械制样.pdf
- 《GB/T 39560.2-2024电子电气产品中某些物质的测定 第2部分:拆解、拆分和机械制样》.pdf
- 《GB/T 39560.303-2024电子电气产品中某些物质的测定 第3-3部分:配有热裂解/热脱附的气相色谱-质谱法(Py/TD-GC-MS)筛选聚合物中的多溴联苯、多溴二苯醚和邻苯二甲酸酯》.pdf
- 中国国家标准 GB/T 39560.303-2024电子电气产品中某些物质的测定 第3-3部分:配有热裂解/热脱附的气相色谱-质谱法(Py/TD-GC-MS)筛选聚合物中的多溴联苯、多溴二苯醚和邻苯二甲酸酯.pdf
文档评论(0)