Alterations in the Interleukin-1Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse 英文参考文献.docVIP

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Alterations in the Interleukin-1Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse 英文参考文献.doc

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Alterations in the Interleukin-1Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse 英文参考文献

AlterationsintheInterleukin-1/Interleukin-1Receptor AntagonistBalanceModulateCardiacRemodeling followingMyocardialInfarctionintheMouse AntonioAbbate1*.,FadiN.Salloum1.,BenjaminW.VanTassell2.,ElenaVecile3,StefanoToldo1 ,Ignacio Seropian1,EleonoraMezzaroma1,2,AldoDobrina3 1Victoria Johnson Research Laboratory and VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, United States of America, 2School of Pharmacy,VirginiaCommonwealthUniversity,Richmond,Virginia,UnitedStatesofAmerica,3DepartmentofPhysiologyandPathology,UniversityofTrieste,Trieste,Italy Abstract Background: Healing after acute myocardial infarction (AMI) is characterized by an intense inflammatory response and increasedInterleukin-1(IL-1)tissueactivity.GeneticallyengineeredmicelackingtheIL-1receptor(IL-1R1-/-,notresponsive to IL-1) or the IL-1 receptor antagonist (IL-1Ra, enhanced response to IL-1) have an altered IL-1/IL-1Ra balance that we hypothesizemodulatesinfarcthealingandcardiacremodelingafterAMI. Methods:IL-1R1-/-andIL-1Ra-/-malemiceandtheircorrespondentwild-types(WT)weresubjectedtopermanentcoronary artery ligation or sham surgery. Infarct size (trichrome scar size), apoptotic cell death (TUNEL) and left ventricular (LV) dimensionsandfunction(echocardiography)weremeasuredpriortoand7daysaftersurgery. Results: When compared with the corresponding WT, IL-1R1-/- mice had significantly smaller infarcts (225%), less cardiomyocyte apoptosis(250%),andreduced LVenlargement(LVend-diastolic diameterincrease [LVEDD], 220%)and dysfunction (LV ejection fraction [LVEF] decrease, 250%), whereas IL-1Ra-/- mice had significantly larger infarcts (+75%), moreapoptosis(5-foldincrease),andmoresevereLVenlargement(LVEDDincrease,+30%)anddysfunction(LVEFdecrease, +70%)(allPvalues,0.05). Conclusions:AnimbalanceinIL-1/IL-1RasignalingattheIL-1R1levelmodulatestheseverityofcardiacremodelingafter AMIinthemouse,withreducedIL-1R1signalingprovidingprotectionandunopposedIL-1R1signalingprovidingharm. Cita