Altered Plasma Apolipoprotein Modifications in Patients with Pancreatic Cancer Protein Characterization and Multi-Institutional Validation 英文参考文献.docVIP

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Altered Plasma Apolipoprotein Modifications in Patients with Pancreatic Cancer Protein Characterization and Multi-Institutional Validation 英文参考文献.doc

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Altered Plasma Apolipoprotein Modifications in Patients with Pancreatic Cancer Protein Characterization and Multi-Institutional Validation 英文参考文献

AlteredPlasmaApolipoproteinModificationsinPatients withPancreaticCancer:ProteinCharacterizationand Multi-InstitutionalValidation KazufumiHonda1,TakujiOkusaka2,KlausFelix3,ShojiNakamori4,NaohiroSata5,HideoNagai5, TatsuyaIoka6,AkihikoTsuchida7,TakeshiShimahara8,MasashiShimahara8,YohichiYasunami9, HideyaKuwabara10,TomohiroSakuma10,YoshihikoOtsuka11,NorihitoOta11,MikiShitashige1, TomooKosuge12,MarkusW.Bu¨chler3,TesshiYamada1* 1DivisionofChemotherapyandClinicalResearch,NationalCancerCenterResearchInstitute,Tokyo,Japan,2HepatobiliaryandPancreaticOncologyDivision,National Cancer Center Hospital, Tokyo, Japan, 3Department of Surgery, University of Heidelberg, Heidelberg, Germany, 4Department of Surgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan, 5Department of Surgery, Jichi Medical University, Shimotsuke, Japan, 6Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, 7Third Department of Surgery, Tokyo Medical University, Tokyo, Japan, 8DepartmentofOralSurgery,OsakaMedicalCollege,Osaka,Japan,9DepartmentofRegenerativeMedicineandTransplantation,FukuokaUniversityFacultyofMedicine, Fukuoka, Japan, 10BioBusiness Group,Mitsui Knowledge Industry, Tokyo, Japan,11Pancreatic CancerDiagnosisProject, Molecuence Corporation, Yokohama,Japan, 12HepatobiliaryandPancreaticSurgeryDivision,NationalCancerCenterHospital,Tokyo,Japan Abstract Background: Among the more common human malignancies, invasive ductal carcinoma of the pancreas has the worst prognosis.Thepooroutcomeseemstobeattributabletodifficultyinearlydetection. Methods: We compared the plasma protein profiles of 112 pancreatic cancer patients with those of 103 sex- and age- matchedhealthycontrols(Cohort1)usinganewlydevelopedmatrix-assistedlaserdesorption/ionization(oMALDI)QqTOF (quadrupoletime-of-flight)massspectrometry(MS)system. Results:Wefoundthathemi-truncatedapolipoproteinAIIdimer(ApoAII-2;17252m/z),unglycosylatedapolipoprotei