Altered Topological Organization of White Matter Structural Networks in Patients with Neuromyelitis Optica 英文参考文献.docVIP

AlteredTopologicalOrganizationofWhiteMatter StructuralNetworksinPatientswithNeuromyelitis Optica YaouLiu1,YunyunDuan1,YongHe2,JunWang2,MingruiXia2,ChunshuiYu1,HuiqingDong3,JingYe3, HelmutButzkueven4,KunchengLi1*,NiShu2* 1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China, 2 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P.R. China, 3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China, 4 Department of Medicine, University of Melbourne, Parkville, Australia Abstract Objective: To investigate the topological alterations of the whole-brain white-matter (WM) structural networks in patients with neuromyelitis optica (NMO). Methods: The present study involved 26 NMO patients and 26 age- and sex-matched healthy controls. WM structural connectivity in each participant was imaged with diffusion-weighted MRI and represented in terms of a connectivity matrix using deterministic tractography method. Graph theory-based analyses were then performed for the characterization of brain network properties. A multiple linear regression analysis was performed on each network metric between the NMO and control groups. Results: The NMO patients exhibited abnormal small-world network properties, as indicated by increased normalized characteristic path length, increased normalized clustering and increased small-worldness. Furthermore, largely similar hub distributions of the WM structural networks were observed between NMO patients and healthy controls. However, regional efficiency in several brain areas of NMO patients was significantly reduced, which were mainly distributed in the default- mode, sensorimotor and visual systems. Furthermore, we have observed increased regional efficiency in a few brain regions such as the orbital p