An Effort to Use Human-Based Exome Capture Methods to Analyze Chimpanzee and Macaque Exomes 英文参考文献.docVIP

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An Effort to Use Human-Based Exome Capture Methods to Analyze Chimpanzee and Macaque Exomes 英文参考文献.doc

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An Effort to Use Human-Based Exome Capture Methods to Analyze Chimpanzee and Macaque Exomes 英文参考文献

AnEfforttoUseHuman-BasedExomeCaptureMethods toAnalyzeChimpanzeeandMacaqueExomes XinJin1,2.,MingzeHe1,2.,BetsyFerguson3.,YuhuanMeng1.,LimeiOuyang2.,JingjingRen2,4. , ThomasMailund5,FeiSun1,LiangdanSun6,7,JuanShen2,MinZhuo1,LiSong2,JufangWang1,FeiLing1, YuqiZhu2,ChristinaHvilsom8,11,HansSiegismund11,XiaomingLiu9,ZhuolinGong2,FangJi9, XinzhongWang9,BoqingLiu9,YuZhang10,JianguoHou10,JingWang10,HuaZhao12,YanyiWang12, XiaodongFang2,GuojieZhang2,JianWang2,XuejunZhang6,7,MikkelH.Schierup10,HongliDu1*, JunWang2,11*,XiaoningWang1,12 * 1School ofBioscience and Bioengineering, South China University of Technology, Guangzhou, China, 2BGI-Shenzhen, Shenzhen, China, 3Primate Genetics Program, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America, 4School of Biological Science and Medical Engineering, Southeast University, Nanjing, China, 5Bioinformatics Research Center, Aarhus University, Aarhus C, Denmark, 6Institute of Dermatology and DepartmentofDermatology,No.1Hospital,AnhuiMedicalUniversity,Hefei,Anhui,China,7StateKeyLaboratoryIncubationBaseofDermatology,MinistryofNational ScienceandTechnology,Hefei,Anhui,China,8ScienceandConservation,CopenhagenZoo,Frederiksberg,Denmark,9South-ChinaPrimateResearchandDevelopment Center, Guangdong Entomological Institute, Guangzhou, China, 10Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China, 11Bioinformatics, DepartmentofBiology,UniversityofCopenhagen,Copenhagen,Denmark,12ChinesePLAGeneralHospital,Beijing,China Abstract Non-human primates have emerged as an important resource for the study of human disease and evolution. The characterizationofgenomicvariationbetweenandwithinnon-humanprimatespeciescouldadvancethedevelopmentof genetically defined non-human primate disease models. However, non-human primate specific reagents that would expedite such research, such as exon-capture tools, are lacking. We evaluated the efficiency of using a human exome capturede