An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles 英文参考文献.docVIP
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An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles 英文参考文献
AnEfficientTargetedDrugDeliverythrough
ApotransferrinLoadedNanoparticles
AthuluriDivakarSaiKrishna1.,RajKumarMandraju1.,GollaKishore1,3,AnandKumarKondapi1,2,3
*
1DepartmentofBiochemistry,UniversityofHyderabad,Hyderabad,India,2DepartmentofBiotechnology,SchoolofLifeSciences,UniversityofHyderabad,Hyderabad,
India,3CentreforNanotechnology,UniversityofHyderabad,Hyderabad,India
Abstract
Background: Cancerous state is a highly stimulated environment of metabolically active cells. The cells under these
conditions over express selective receptors for assimilation of factors essential for growth and transformation. Such
receptorswouldserveaspotentialtargetsforthespecificligandmediatedtransportofpharmaceuticallyactivemolecules.
Thepresentstudydemonstratesthespecificityandefficacyofproteinnanoparticleofapotransferrinfortargeteddeliveryof
doxorubicin.
Methodology/PrincipalFindings:Apotransferrinnanoparticlesweredevelopedbysol-oilchemistry.Acomparativeanalysis
of efficiency of drug delivery in conjugated and non-conjugated forms of doxorubicin to apotransferrin nanoparticle is
presented.Thesphericalshapedapotransferrinnanoparticles(nano)havediametersof25–50gm,whichincreaseto60–
80gm upon direct loading of drug (direct-nano), and showed further increase in dimension (75–95gm) in conjugated
nanoparticles(conj-nano).Thecompetitiveexperimentswiththetransferrinreceptorspecificantibodyshowedtheentryof
bothconj-nanoanddirect-nanointothecellsthroughtransferrinreceptormediatedendocytosis.Resultsofvariousstudies
conductedclearlyestablishthesuperiorityofthedirect-nanooverconj-nanoviz.(a)localizationstudiesshowedcomplete
releaseofdrugveryearly,evenasearlyas30minaftertreatment,withthedruglocalizinginthetargetorganelle(nucleus)
(b)pharmacokineticstudiesshowedenhanceddrugconcentrations,incirculationwithsustainablehalf-life(c)thestudies
also demonstrated efficient drug delivery, and an enhanced inhibition of proliferation in cancer cells. Tissue distribution
analysisshowedintravenousadministra
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