An Exploratory Pathways Analysis of Temporal Changes Induced by Spinal Cord Injury in the Rat Bladder Wall Insights on Remodeling and Inflammation 英文参考文献.docVIP

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An Exploratory Pathways Analysis of Temporal Changes Induced by Spinal Cord Injury in the Rat Bladder Wall Insights on Remodeling and Inflammation 英文参考文献.doc

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An Exploratory Pathways Analysis of Temporal Changes Induced by Spinal Cord Injury in the Rat Bladder Wall Insights on Remodeling and Inflammation 英文参考文献

AnExploratoryPathwaysAnalysisofTemporalChanges InducedbySpinalCordInjuryintheRatBladderWall: InsightsonRemodelingandInflammation SilviaWognum1,2,ClaudioE.Lagoa3¤a,JiroNagatomi1,2¤b,MichaelS.Sacks1,2,YoramVodovotz2,3,4 * 1DepartmentofBioengineering,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica,2TheMcGowanInstitute,Pittsburgh,Pennsylvania,United States ofAmerica,3DepartmentofSurgery, UniversityofPittsburgh,Pittsburgh,Pennsylvania,United States ofAmerica, 4Center for Inflammation andRegenerative Modeling,TheMcGowanInstitute,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica Abstract Background:Spinalcordinjuries(SCI)canleadtoseverebladderpathologiesassociatedwithinflammation,fibrosis,and increased susceptibility to urinary tract infections. We sought to characterize the complex pathways of remodeling, inflammation,andinfectionintheurinarybladderatthelevelofthetranscriptomeinaratmodelofSCI,usingpathways analysisbioinformatics. Methodology/PrincipalFindings:ExperimentaldatawereobtainedfromthestudyofNagatomietal.(BiochemBiophysRes Commun334:1159).Inthisstudy,bladdersfromratssubjectedtosurgicalSCIwereobtainedat3,7or25dayspost-surgery, and Affymetrix GeneChipH Rat Genome U34A arrays were used for cRNA hybridizations. In the present study, Ingenuity PathwaysAnalysis(IngenuityHSystems,)ofdifferentiallyexpressedgeneswasperformed.Analysisof focusgenesinnetworks,functionalanalysis,andcanonicalpathwayanalysisreinforcedourpreviousfindingsrelatedtothe presenceofup-regulatedgenesinvolvedintissueremodeling,suchaslysyloxidase,tropoelastin,TGF-b1,andIGF-1.This analysis also highlighteda central role for inflammation and infection, evidenced by networks containing genessuch as CD74,S100A9,andTHY1. Conclusions/Significance: Our findings suggest that tissue remodeling, infection, inflammation, and tissue damage/ dysfunctionallplayaroleintheurinarybladder,inthecomplexresponsetoSCI. Citation:WognumS,LagoaCE,NagatomiJ,SacksMS,VodovotzY(2009)AnEx