An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema 英文参考文献.docVIP

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An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema 英文参考文献.doc

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An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema 英文参考文献

o Openaccess,freelyavailableonline PL S MEDICINE AnImmuneBasisforLungParenchymal DestructioninChronicObstructive PulmonaryDiseaseandEmphysema Sandra Grumelli1,David B.Corry1,2,Li-Zhen Song1,Ling Song1,Linda Green3,Joseph Huh4,Joan Hacken5, Rafael Espada6,Remzi Bag1,Dorothy E.Lewis2,Farrah Kheradmand1* 1DepartmentofMedicine,SectionofPulmonaryandCriticalCare,BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica, 2DepartmentofImmunology, BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica, 3DepartmentofPathology,MichaelE.DeBakeyVeteransAffairsMedicalCenter,Houston,Texas, United States of America, 4Department of Surgery, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America, 5Department of Radiology,MichaelE.DeBakeyVeteransAffairsMedicalCenter,Houston,Texas,UnitedStatesofAmerica, 6DepartmentofSurgery,BaylorCollegeofMedicine,Houston, Texas,UnitedStatesofAmerica CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT AuthorContributions:D.B.Corry, D.E.Lewis,andF.Kheradmand designedthestudy.S.Grumelli,L.- Z.Song,L.Green,L.Song,J. Hacken,andF.Kheradmandana- lyzedthedata.J.Huh,R.Espada,R. Bag,andF.Kheradmandenrolled patients.D.B.Corry,D.E.Lewis, andF.Kheradmandcontributedto writingthepaper. Background Chronicobstructivepulmonarydiseaseandemphysemaareafrequentresultoflong-term smoking, but the exact mechanisms, specifically which typesof cells are associatedwith the lungdestruction,areunclear. MethodsandFindings AcademicEditor:PeterJ.Barnes, NationalHeartandLungInstitute, UnitedKingdom Westudieddifferentsubsetsoflymphocytestakenfromportionsofhumanlungsremoved surgicallytofindoutwhichlymphocyteswerethemostfrequent,whichcell-surfacemarkers theselymphocytesexpressed,andwhetherthelymphocytessecretedanyspecificfactorsthat couldbeassociatedwithdisease.Wefoundthatlossoflungfunctioninpatientswithchronic obstructive pulmonary disease and emphysema was associated with a high pe