An fMRI Study of the Neural Systems Involved in Visually Cued Auditory Top-Down Spatial and Temporal Attention 英文参考文献.docVIP

An fMRI Study of the Neural Systems Involved in Visually Cued Auditory Top-Down Spatial and Temporal Attention 英文参考文献.doc

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An fMRI Study of the Neural Systems Involved in Visually Cued Auditory Top-Down Spatial and Temporal Attention 英文参考文献

AnfMRIStudyoftheNeuralSystemsInvolvedinVisually CuedAuditoryTop-DownSpatialandTemporal Attention ChunlinLi1,2,KeweiChen3,HongbinHan4,DehuaChui4,5,JinglongWu1* 1BiomedicalEngineeringLaboratory, Graduate School ofNaturalScienceand Technology, Okayama University, Okayama,Japan, 2School ofBiomedical Engineering, CapitalMedicalUniversity,YouAnMen,Beijing,China,3BannerAlzheimer’sInstitute,DepartmentofPsychiatry,Phoenix,Arizona,UnitedStatesofAmerica,4Department of Neurology, Peking University Third Hospital, Beijing, China, 5Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, MinistryofEducationandMinistryofPublicHealth,HealthScienceCenter,PekingUniversity,Beijing,China Abstract Top-downattentiontospatialandtemporalcueshasbeenthoroughlystudiedinthevisualdomain.However,becausethe neural systems that areimportant for auditory top-down temporal attention (i.e., attention based on time interval cues) remainundefined,thedifferencesinbrainactivitybetweendirectedattentiontoauditoryspatiallocation(comparedwith timeintervals)areunclear.UsingfMRI(magneticresonanceimaging),wemeasuredtheactivationscausedbycue-target paradigmsbyinducingthevisualcueingofattentiontoanauditorytargetwithinaspatialortemporaldomain.Imaging results showed that the dorsal frontoparietal network (dFPN), which consists of the bilateral intraparietal sulcus and the frontaleyefield,respondedtospatialorientingofattention,butactivitywasabsentinthebilateralfrontaleyefield(FEF) during temporal orienting of attention. Furthermore, the fMRI results indicated that activity in the right ventrolateral prefrontalcortex(VLPFC)wassignificantlystrongerduringspatialorientingofattentionthanduringtemporalorientingof attention,whiletheDLPFCshowednosignificantdifferencesbetweenthetwoprocesses.Weconcludethatthebilateral dFPNandtherightVLPFCcontributetoauditoryspatialorientingofattention.Furthermore,specificactivationsrelatedto temporalcognitionwereconfirmedwithinthesuperioroccipitalgyru

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