An fMRI Study of the Neural Systems Involved in Visually Cued Auditory Top-Down Spatial and Temporal Attention 英文参考文献.docVIP
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An fMRI Study of the Neural Systems Involved in Visually Cued Auditory Top-Down Spatial and Temporal Attention 英文参考文献
AnfMRIStudyoftheNeuralSystemsInvolvedinVisually
CuedAuditoryTop-DownSpatialandTemporal
Attention
ChunlinLi1,2,KeweiChen3,HongbinHan4,DehuaChui4,5,JinglongWu1*
1BiomedicalEngineeringLaboratory, Graduate School ofNaturalScienceand Technology, Okayama University, Okayama,Japan, 2School ofBiomedical Engineering,
CapitalMedicalUniversity,YouAnMen,Beijing,China,3BannerAlzheimer’sInstitute,DepartmentofPsychiatry,Phoenix,Arizona,UnitedStatesofAmerica,4Department
of Neurology, Peking University Third Hospital, Beijing, China, 5Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience,
MinistryofEducationandMinistryofPublicHealth,HealthScienceCenter,PekingUniversity,Beijing,China
Abstract
Top-downattentiontospatialandtemporalcueshasbeenthoroughlystudiedinthevisualdomain.However,becausethe
neural systems that areimportant for auditory top-down temporal attention (i.e., attention based on time interval cues)
remainundefined,thedifferencesinbrainactivitybetweendirectedattentiontoauditoryspatiallocation(comparedwith
timeintervals)areunclear.UsingfMRI(magneticresonanceimaging),wemeasuredtheactivationscausedbycue-target
paradigmsbyinducingthevisualcueingofattentiontoanauditorytargetwithinaspatialortemporaldomain.Imaging
results showed that the dorsal frontoparietal network (dFPN), which consists of the bilateral intraparietal sulcus and the
frontaleyefield,respondedtospatialorientingofattention,butactivitywasabsentinthebilateralfrontaleyefield(FEF)
during temporal orienting of attention. Furthermore, the fMRI results indicated that activity in the right ventrolateral
prefrontalcortex(VLPFC)wassignificantlystrongerduringspatialorientingofattentionthanduringtemporalorientingof
attention,whiletheDLPFCshowednosignificantdifferencesbetweenthetwoprocesses.Weconcludethatthebilateral
dFPNandtherightVLPFCcontributetoauditoryspatialorientingofattention.Furthermore,specificactivationsrelatedto
temporalcognitionwereconfirmedwithinthesuperioroccipitalgyru
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