Analysis of Stochastic Strategies in Bacterial Competence A Master Equation Approach 英文参考文献.docVIP
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Analysis of Stochastic Strategies in Bacterial Competence A Master Equation Approach 英文参考文献
AnalysisofStochasticStrategiesinBacterial
Competence:AMasterEquationApproach
SandraH.Dandach,MustafaKhammash*
DepartmentofMechanicalandIndustrialEngineering,UniversityofCalifornia,SantaBarbara,SantaBarbara,California,UnitedStatesofAmerica
Abstract
Competenceisatransientlydifferentiatedstatethatcertainbacterialcellsreachwhenfacedwithastressfulenvironment.
Entranceintocompetencecanbeattributedtotheexcitabilityofthedynamicsgoverningthegeneticcircuitthatregulates
thiscellularbehavior.Likemanybiologicalbehaviors,entranceintocompetenceisastochasticevent.Inthiscasecellular
noiseisresponsiblefordrivingthecellfromavegetativestateintocompetenceandback.Inthisworkwepresentanovel
numericalmethodfortheanalysisofstochasticbiochemicaleventsanduseittostudytheexcitabledynamicsresponsible
for competence in Bacillus subtilis.Starting with aFiniteState Projection (FSP) solution of thechemical master equation
(CME),wedevelopefficientnumericaltoolsforaccuratelycomputingcompetenceprobability.Additionally,weproposea
newapproach forthesensitivity analysis ofstochastic events andutilizeittoelucidate therobustness properties of the
competenceregulatorygeneticcircuit.Wealsoproposeandimplementanumericalmethodtocalculatetheexpectedtime
ittakesacelltoreturnfromcompetence.Althoughthisstudyisfocusedonanexampleofcell-differentiationinBacillus
subtilis,ourapproachcanbeappliedtoawiderangeofstochasticphenomenainbiologicalsystems.
Citation:DandachSH,KhammashM(2010)AnalysisofStochasticStrategiesinBacterialCompetence:AMasterEquationApproach.PLoSComputBiol6(11):
e1000985.doi:10.1371/journal.pcbi.1000985
Editor:ChristopherV.Rao,UniversityofIllinoisatUrbana-Champaign,UnitedStatesofAmerica
ReceivedMay11,2010;AcceptedOctober4,2010;PublishedNovember11,2010
Copyright:?2010Dandach,Khammash.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:Theauthora
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