Angiopoietin-2 Modulator of Vascular Permeability in Acute Lung Injury 英文参考文献.docVIP

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Angiopoietin-2 Modulator of Vascular Permeability in Acute Lung Injury 英文参考文献.doc

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Angiopoietin-2 Modulator of Vascular Permeability in Acute Lung Injury 英文参考文献

respPectives Angiopoietin-2: Modulator of Vascular Permeability in Acute Lung Injury? Tomoki Hashimoto, Jean-Francois Pittet* T ie (tyrosine kinase with immunoglobulin-like loop and epidermal growth factor tumorigenesis) blood vessel formation, or angiogenesis (reviewed in [2]). Neither Ang1 nor Ang2 can trigger an angiogenic response alone, but both enhance vascular endothelial growth factor (VEGF)–induced angiogenesis. Ang1 signaling via Tie2 promotes vessel maturation and quiescence, whereas Ang2 blocks Ang1/Tie2 signaling, and this leads to either angiogenesis or vessel regression and apoptosis, depending on the presence of VEGF or other angiogenic factors. with the extracellular matrix and junctional proteins, and enhances barrier function [3]. For example, Ang1 has been shown to protect the adult vasculature against plasma leakage induced by VEGF [4] by inhibiting the calcium in?ux into the cells [5]. In addition, the activation of Ang1/Tie2 signaling attenuates H2O2- induced apoptosis by activating the phosphoinositol 3-kinase/Akt pathway [6]. These results suggest that Ang1 has anti-in?ammatory properties. homology domains) represents a novel class of receptor tyrosine kinases that are mostly expressed by vascular endothelial cells. There are currently two known members in this class: Tie1 (also described as Tie) and Tie2 (also known as Tek; reviewed in [1]). During embryonic development, endothelial cells express both Tie1 and Tie2 receptors. Tie2 is also expressed in quiescent endothelial cells in adult tissues. Unlike Tie1, Tie2 has well-described ligands called angiopoietins. Of the four currently known angiopoietins (Ang1–4), the best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). The functional consequences of A recent study showed that the adenoviral gene transfer of Ang1 can protect mice against endotoxic shock induced by Escherichia coli endotoxin, and is associated with an improvement in hemodynamic function, reduced lung injur