Ankle-Brachial Index A Simple Way to Predict Mortality among Patients on Hemodialysis - A Prospective Study 英文参考文献.docVIP
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Ankle-Brachial Index A Simple Way to Predict Mortality among Patients on Hemodialysis - A Prospective Study 英文参考文献
Ankle-BrachialIndex:ASimpleWaytoPredictMortality
amongPatientsonHemodialysis-AProspectiveStudy
ZaidaNoemyCabreraJimenez,BeneditoJorgePereira,Joa?oEgidioRoma?oJr,SoniaCristinada
SilvaMakida,HugoAbensur,RosaMariaAffonsoMoyses,RosileneMottaElias*
RenalDivision,InternalMedicine,HospitaldasCl?′nicas,UniversityofSa?o PauloSchoolofMedicine,Sa?o Paulo,Brazil
Abstract
Background:Ankle-brachialindex(ABI)canaccessperipheralarterydiseaseandpredictmortalityinprevalentpatientson
hemodialysis.However,ABIhasnotyetbeentestedinincidentpatients,whopresentsignificantmortality.Typically,ABIis
measuredbyDoppler,whichisnotalwaysavailable,limitingitsuseinmostpatients.WethereforehypothesizedthatABI,
evaluatedbyasimplifiedmethod,canpredictmortalityinanincidenthemodialysispopulation.
Methodology/PrincipalFindings:Westudied119patientswithESRDwhohadstartedhemodialysisthreetimesweekly.ABI
wascalculatedbyusingtwooscillometricbloodpressuredevicessimultaneously.Patientswerefolloweduntildeathorthe
endofthestudy.ABIwascategorizedintwogroupsnormal(0.9–1.3)orabnormal(,0.9and.1.3).Therewere33deaths
during a median follow-up of 12months (from 3 to 24months). Age (1year) (hazard of ratio, 1.026; p=0.014) and ABI
abnormal(hazardratio,3.664;p=0.001)wereindependentlyrelatedtomortalityinamultipleregressionanalysis.
Conclusions: An easy and inexpensive technique tomeasure ABI was tested and showed tobe significant in predicting
mortality.BothlowandhighABIwereassociatedtomortalityinincidentpatientsonhemodialysis.Thistechniqueallows
nephrologists to identify high-risk patients and gives the opportunity of early intervention that could alter the natural
progressionofthispopulation.
Citation:JimenezZNC,PereiraBJ,Roma?oJEJr,MakidaSCdS,AbensurH,etal.(2012)Ankle-BrachialIndex:ASimpleWaytoPredictMortalityamongPatientson
Hemodialysis-AProspectiveStudy.PLoSONE7(7):e42290.doi:10.1371/journal.pone.0042290
Editor:EmmanuelA.Burdmann,UniversityofSaoPauloMedicalSchool,Brazil
ReceivedMay23,2012;AcceptedJuly5,2012;Publis
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