Assessing Statistical Significance in Microarray Experiments Using the Distance Between Microarrays 英文参考文献.docVIP

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Assessing Statistical Significance in Microarray Experiments Using the Distance Between Microarrays 英文参考文献.doc

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Assessing Statistical Significance in Microarray Experiments Using the Distance Between Microarrays 英文参考文献

AssessingStatisticalSignificanceinMicroarray ExperimentsUsingtheDistanceBetweenMicroarrays DouglasHayden1*,PeterLazar1,DavidSchoenfeld1,2 forTheInflammationandtheHostResponseto InjuryInvestigators 1BiostatisticsCenter,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,2HarvardSchoolofPublicHealth,Boston,Massachusetts,United StatesofAmerica Abstract We propose permutation tests based on the pairwise distances between microarrays to compare location, variability, or equivalence of gene expression between two populations. For these tests the entire microarray or some pre-specified subset of genes is the unit of analysis. The pairwise distances only have to be computed once so the procedure is not computationallyintensivedespitethehighdimensionalityofthedata.AnRsoftwarepackage,permtest,implementingthe methodisfreelyavailablefromtheComprehensiveRArchiveNetworkat. Citation: Hayden D, Lazar P, Schoenfeld D, for The Inflammation and the Host Response to Injury Investigators (2009) Assessing Statistical Significance in MicroarrayExperimentsUsingtheDistanceBetweenMicroarrays.PLoSONE4(6):e5838.doi:10.1371/journal.pone.0005838 Editor:KerbyShedden,UniversityofMichigan,UnitedStatesofAmerica ReceivedNovember20,2008;AcceptedApril11,2009;PublishedJune16,2009 Copyright: ? 2009 Hayden et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisresearchwassupportedbyaLargeScaleCollaborativeResearchGrantfromtheNationalInstituteofGeneralMedicalSciences,U54GM-62119-02. This funding source provided the data presented in the example and approved publication but had no role in the analysis, development of the proposed methodology,orwritingofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:dhayden@ Introduction off threshold for significance and