Association between TGFBR1 Polymorphisms and Cancer Risk A Meta-Analysis of 35 Case-Control Studies 英文参考文献.docVIP

下载本文档

11
0
约4万字
约 10页
2017-05-11 发布于上海
举报
版权申诉

Association between TGFBR1 Polymorphisms and Cancer Risk A Meta-Analysis of 35 Case-Control Studies 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Association between TGFBR1 Polymorphisms and Cancer Risk A Meta-Analysis of 35 Case-Control Studies 英文参考文献

AssociationbetweenTGFBR1PolymorphismsandCancer Risk:AMeta-Analysisof35Case-ControlStudies Yong-qiangWang1.,Xiao-weiQi2.,FanWang3,JunJiang2*,Qiao-nanGuo1* 1Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, China, 2Breast Disease Center, Southwest Hospital, Third Military Medical University,Chongqing,China,3DepartmentofOncology,JiangjinCentralHospital,Jiangjin,Chongqing,China Abstract Background:NumerousepidemiologicalstudieshaveevaluatedtheassociationbetweenTGFBR1polymorphismsandthe riskofcancer,however,theresultsremaininconclusive.Toderiveamorepreciseestimationoftherelation,weconducteda comprehensivemeta-analysisofallavailablecase-controlstudiesrelatingtheTGFBR1*6AandIVS7+24G. Apolymorphisms oftheTGFBR1genetotheriskofcancer. Methods:Eligiblestudieswereidentifiedbysearchofelectronicdatabases.Overallandsubgroupanalyseswereperformed. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the associations between TGFBR1*6A and IVS7+24G.Apolymorphismsandcancerrisk. Results:Atotalof35studieswereidentified,32with19,767casesand18,516controlsforTGFBR1*6Apolymorphismand12 with4,195casesand4,383controlsforIVS7+24G.Apolymorphism.ForTGFBR1*6A,significantlyelevatedcancerriskwas found in all genetic models (dominant OR=1.11, 95% CI=1.04,1.18; recessive: OR=1.36, 95% CI=1.11,1.66; additive: OR=1.13,95%CI=1.05,1.20).Insubgroupanalysisbasedoncancertype,increasedcancerriskwasfoundinovarianand breast cancer. For IVS7+24G.A, significant correlation with overall cancer risk (dominant: OR=1.39, 95% CI=1.15,1.67; recessive:OR=2.23,95%CI=1.26,3.92;additive:OR=1.43,95%CI=1.14,1.80)wasfound,especiallyinAsianpopulation. Inthesubgroupanalysisstratifiedbycancertype,significantassociationwasfoundinbreastandcolorectalcancer. Conclusions:OurinvestigationsdemonstratethatTGFBR1*6AandIVS7+24G.ApolymorphismsofTGFBR1areassociated withthesusceptibilityofcancer,andfurtherfunctionalresearchshouldbeperformedtoexplaintheinconsistentresultsin differen