AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana 英文参考文献.docVIP

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AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana 英文参考文献.doc

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AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana 英文参考文献

AvrRpm1MissenseMutationsWeaklyActivateRPS2- MediatedImmuneResponseinArabidopsisthaliana KarenA.Cherkis1,3,BrendaR.S.Temple7,9,Eui-HwanChung1,JohnSondek6,7,8,JefferyL.Dangl1,2,3,4,5 * 1Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 2Howard Hughes Medical Institute, University of North Carolina,ChapelHill,NorthCarolina,UnitedStatesofAmerica,3CurriculuminGeneticsandMolecularBiology,UniversityofNorthCarolina,ChapelHill,NorthCarolina, UnitedStatesofAmerica,4DepartmentofMicrobiologyandImmunology,UniversityofNorthCarolina,ChapelHill,NorthCarolina,UnitedStatesofAmerica,5Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America, 6Department of Pharmacology, University of North Carolina,ChapelHill,NorthCarolina,UnitedStatesofAmerica,7DepartmentofBiochemistryandBiophysics,UniversityofNorthCarolina,ChapelHill,NorthCarolina, UnitedStatesofAmerica,8LinebergerComprehensiveCancerCenter,UniversityofNorthCarolina,ChapelHill,NorthCarolina,UnitedStatesofAmerica,9R.L.Juliano StructuralBioinformaticsCoreFacility,UniversityofNorthCarolina,ChapelHill,NorthCarolina,UnitedStatesofAmerica Abstract Plants recognize microbes via specific pattern recognition receptors that are activated by microbe-associated molecular patterns (MAMPs), resulting in MAMP-triggered immunity (MTI). Successful pathogens bypass MTI in genetically diverse hosts via deployment of effectors (virulence factors) that inhibit MTI responses, leading to pathogen proliferation. Plant pathogenic bacteria like Pseudomonas syringae utilize a type III secretion system to deliver effectors into cells. These effectors can contribute to pathogen virulence or elicit disease resistance, depending upon the host plant genotype. In disease resistant genotypes, intracellular immune receptors, typically belonging to the nucleotide binding leucine-rich repeat family of proteins, perceive bacterial effector(s) and ini