Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity 英文参考文献.docVIP

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Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity 英文参考文献.doc

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Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity 英文参考文献

BorreliarecurrentisEmploysaNovelMultifunctional SurfaceProteinwithAnti-Complement,Anti-Opsonic andInvasivePotentialtoEscapeInnateImmunity SonjaGrosskinsky1,MelanieSchott1,ChristianeBrenner1,SallyJ.Cutler2,PeterKraiczy3,PeterF.Zipfel4, MarkusM.Simon5,ReinhardWallich1* 1Infectious Immunology, Institute for Immunology, University of Heidelberg, Heidelberg, Germany, 2School of Health and Bioscience, University of East London, Stratford,London,UnitedKingdom,3InstituteofMedicalMicrobiologyandInfectionControl,UniversityHospitalofFrankfurt,Frankfurt/Main,Germany,4Departmentof InfectionBiology,Leibniz-InstituteforNaturalProductsResearch,Jena,Germany,5MetschnikoffLaboratory,Max-Planck-InstituteforImmunobiology,Freiburg,Germany Abstract Borreliarecurrentis,theetiologicagentoflouse-bornerelapsingfeverinhumans,hasevolvedstrategies,includingantigenic variation,toevadeimmunedefence,therebycausingseverediseaseswithhighmortalityrates.Hereweidentifyforthefirst timeamultifunctionalsurfacelipoproteinofB.recurrentis,termedHcpA,anddemonstratethatitbindshumancomplement regulators,FactorH,CFHR-1,andsimultaneously,thehostproteaseplasminogen.CellsurfaceboundfactorHwasfoundto retainitsactivityandtoconferresistancetocomplementattack.Moreover,ectopicexpressionofHcpAinaB.burgdorferi B313 strain, deficient in Factor H binding proteins, protected the transformed spirochetes from complement-mediated killing.Furthermore,HcpA-boundplasminogen/plasminendowsB.recurrentiswiththepotentialtoresistopsonizationand to degrade extracellular matrix components. Together, the present study underscores the high virulence potential of B. recurrentis. The elucidation of the molecular basis underlying the versatile strategies of B. recurrentis to escape innate immunity and to persist in human tissues, including the brain, may help to understand the pathological processes underlyinglouse-bornerelapsingfever. Citation: Grosskinsky S,Schott M, Brenner C, Cutler SJ,Kraiczy P, et al.(2009) Borrelia recurrentis Employs