Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis 英文参考文献.docVIP

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Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis 英文参考文献.doc

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Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis 英文参考文献

BrainViscoelasticityAlterationinChronic-Progressive MultipleSclerosis Kaspar-JoscheStreitberger1,IngolfSack1*,DagmarKrefting1,CasparPfu¨ller2,Ju¨rgenBraun3, FriedemannPaul2,5.,JensWuerfel2,4. 1DepartmentofRadiology,Charite′ –UniversityMedicineBerlin,Berlin,Germany,2NeuroCureClinicalResearchCenterandExperimentalandClinicalResearchCenter, Charite′ –UniversityMedicineBerlinandMaxDelbrueckCenterforMolecularMedicine,Berlin,Germany,3InstituteofMedicalInformatics,Charite′ –UniversityMedicine Berlin, Berlin,Germany, 4Institute of Neuroradiology, University Luebeck,Luebeck,Germany, 5Clinical and Experimental Multiple Sclerosis Research Center, Charite′ - UniversityMedicineBerlin,Berlin,Germany Abstract Introduction: Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity.MagneticResonanceElastography(MRE)isanoveltechniquethatdirectlyvisualizesandquantitativelymeasures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressivediseasecoursesofMS. Methods: Wedeterminedviscoelastic parametersofthebrainparenchyma in23MSpatients withprimaryorsecondary chronicprogressivediseasecourseincomparisonto38age-andgender-matchedhealthyindividualsbymultifrequency MRE,andcorrelatedtheresultswithclinicaldata,T2lesionloadandbrainvolume.Twoviscoelasticparameters,theshear elasticity m and the powerlaw exponent a, were deduced according to the springpot model and compared to literature valuesofrelapsing-remittingMS. Results:Inchronic-progressiveMSpatients,mandawerereducedby20.5%and6.1%,respectively,comparedtohealthy controls.MRvolumetryyieldedaweakercorrelation:TotalbrainvolumelossinMSpatientswasintherangeof7.5%and 1.7%consideringthebrainparenchymalfraction.Allfindingsweresignificant(P,0.001). Conclusions: Chronic-progressive