Campylobacter jejuni Colonization in Wild Birds Results from an Infection Experiment 英文参考文献.docVIP
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Campylobacter jejuni Colonization in Wild Birds Results from an Infection Experiment 英文参考文献
CampylobacterjejuniColonizationinWildBirds:Results
fromanInfectionExperiment
JonasWaldenstro¨m1,2*,DianaAxelsson-Olsson1,Bjo¨rnOlsen1,3,DennisHasselquist2,PetraGriekspoor1,
LenaJansson4,SusannTeneberg4,LovisaSvensson1,PatrikEllstro¨m1,5
1SectionforZoonoticEcologyandEpidemiology,LinnaeusUniversity,Kalmar,Sweden,2DepartmentofAnimalEcology,LundUniversity,Lund,Sweden,3Department
ofInfectious Diseases, UppsalaUniversity, Uppsala, Sweden,4Department ofMedicalBiochemistryandCellBiology,UniversityofGothenburg,Gothenburg,Sweden,
5DepartmentofMedicalSciences,ClinicalBacteriology,UniversityofUppsalaandUppsalaUniversityHospital,Uppsala,Sweden
Abstract
Campylobacterjejuniisacommoncauseofbacterialgastroenteritisinmostpartsoftheworld.Thebacteriumhasabroad
host range and has been isolated from many animals and environments. To investigate shedding patterns and putative
effectsonanavianhost,wedevelopedacolonizationmodelinwhichawildbirdspecies,theEuropeanRobin Erithacus
rubecula,wasinoculatedorallywithC.jejunifromeitherahumanpatientorfromanotherwildbirdspecies,theSongThrush
Turdusphilomelos.Thesetwoisolatesweregeneticallydistinctfromeachotherandprovokedverydifferenthostresponses.
TheSongThrushisolatecolonizedallchallengedbirdsandcolonizationlasted6.8daysonaverage.Birdsinfectedwiththis
isolatealsoshowedatransientbutsignificantdecreaseinbodymass.Thehumanisolatedidnotcolonizethebirdsand
couldbedetectedonlyinthefecesofthebirdsshortlyafterinoculation.EuropeanRobinsinfectedwiththewildbirdisolate
generatedaspecificantibodyresponsetoC.jejunimembraneproteinsfromtheavianisolate,whichalsowascross-reactive
tomembraneproteinsofthehumanisolate.Incontrast,EuropeanRobinsinfectedwiththehumanisolatedidnotmounta
significantresponsetobacterialmembraneproteinsfromeitherofthetwoisolates.Thedifferenceincolonizationability
couldindicatehostadaptations.
Citation:Waldenstro¨mJ,Axelsson-OlssonD,OlsenB,HasselquistD,GriekspoorP,etal.(2010)CampylobacterjejuniColonizationinWildBirds:Resultsfroman
Infe
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