Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity 英文参考文献.docVIP
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Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity 英文参考文献
DetrimentalEffectsofEnvironmentalTobaccoSmokein
RelationtoAsthmaSeverity
SuzyA.A.Comhair1*,BenjaminM.Gaston2,KristinS.Ricci1,JeffreyHammel1,RaedA.Dweik1,3 ,W.
GeraldTeague2,DeborahMeyers4,ElizabethJ.Ampleford4,EugeneR.Bleecker4,WilliamW.Busse5,
WilliamJ.Calhoun6,MarioCastro7,KianFanChung8,DouglasCurran-Everett9,ElliotIsrael10,W.Nizar
Jarjour5,WendyMoore4,StephenP.Peters4,SallyWenzel11,StanleyL.Hazen12,SerpilC.Erzurum1,3*
fortheNationalHeartLungBloodInstituteSevereAsthmaResearchProgram(SARP)¤
1DepartmentsofPathobiology,ClevelandClinic,Cleveland,Ohio,UnitedStatesofAmerica, 2DepartmentofPediatrics,UniversityofVirginia,Charlottesville,Virginia,
UnitedStatesofAmerica,3RespiratoryInstitute,ClevelandClinic,Cleveland,Ohio,UnitedStatesofAmerica,4Pulmonary,CriticalCare,AllergyandImmunologicDiseases,
WakeForestUniversity,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,5DepartmentofInternalMedicine,UniversityofWisconsin,Madison,Wisconsin,United
StateofAmerica,6DepartmentofInternalMedicine,UniversityofTexasMedicalBranchatGalveston,Galveston,Texas,UnitedStatesofAmerica,7InternalMedicine/
PulmonaryandCriticalCareMedicine,WashingtonUniversity,StLouis,Missouri,UnitedStatesofAmerica,8NationalHeartandLungInstitute,ImperialCollegeSchoolof
Medicine,London,UnitedKingdom,9DivisionofBiostatistics,NationalJewishCenter,Denver,Colorado,UnitedStatesofAmerica,10DepartmentofMedicine,Brigham
andWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica,11AsthmaInstitute,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica,
12DepartmentofCellBiologyandCenterforCardiovascularDiagnosticsandPrevention,ClevelandClinic,Cleveland,Ohio,UnitedStatesofAmerica
Abstract
Background: Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful
consequencesofETSinrelationtoasthmaseverityareunknown.
Methods: In a multicenter study of severe asthma, we assessed the impact of ETS exposure on morbidity, health care
utilizationandlungfunctions;andac
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