Diet and Cell Size Both Affect Queen-Worker Differentiation through DNA Methylation in Honey Bees (Apis mellifera, Apidae) 英文参考文献.docVIP

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Diet and Cell Size Both Affect Queen-Worker Differentiation through DNA Methylation in Honey Bees (Apis mellifera, Apidae) 英文参考文献.doc

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Diet and Cell Size Both Affect Queen-Worker Differentiation through DNA Methylation in Honey Bees (Apis mellifera, Apidae) 英文参考文献

DietandCellSizeBothAffectQueen-Worker DifferentiationthroughDNAMethylationinHoneyBees (Apismellifera,Apidae) YuanYuanShi1,ZacharyY.Huang2,3*,ZhiJiangZeng1*,ZiLongWang1,XiaoBoWu1,WeiYuYan1 1HoneybeeResearchInstitute,JiangxiAgriculturalUniversity,Nanchang,Jiangxi,China,2DepartmentofEntomology,MichiganStateUniversity,EastLansing,Michigan, UnitedStatesofAmerica,3Ecology,EvolutionaryBiologyandBehaviorProgram,MichiganStateUniversity,EastLansing,Michigan,UnitedStatesofAmerica Abstract Background:Younglarvaeofthehoneybee(Apismellifera)aretotipotent;theycanbecomeeitherqueens(reproductives) orworkers(largelysterilehelpers).DNAmethylationhasbeenshowntoplayanimportantroleinthisdifferentiation.Inthis study,weexaminethecontributionsofdietandcellsizetocastedifferentiation. Methodology/Principal Findings: We measured the activity and gene expression of one key enzyme involved in methylation, Dnmt3; theratesof methylationin thegene dynactin p62;as wellas morphological characteristics of adult beesdevelopedeitherfromlarvaefedwithworkerjellyorroyaljelly;andlarvaeraisedineitherqueenorworkercells.We showthatbothdiettypeandcellsizecontributedtothequeen-workerdifferentiation,andthatthetwofactorsaffected differentmethylationsitesinsidethesamegenedynactinp62. Conclusions/Significance:WeconfirmpreviousfindingsthatDnmt3playsacriticalroleinhoneybeecastedifferentiation. Further,weshowforthefirsttimethatcellsizealsoplaysaroleininfluencinglarvaldevelopmentwhendietiskeptthe same. Citation:ShiYY,HuangZY,ZengZJ,WangZL,WuXB,etal.(2011)DietandCellSizeBothAffectQueen-WorkerDifferentiationthroughDNAMethylationin HoneyBees(Apismellifera,Apidae).PLoSONE6(4):e18808.doi:10.1371/journal.pone.0018808 Editor:MichaelFreitag,OregonStateUniversity,UnitedStatesofAmerica ReceivedNovember3,2010;AcceptedMarch12,2011;PublishedApril26,2011 Copyright:?2011Shietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,p