Discrete Choice Experiment to Evaluate Factors That Influence Preferences for Antibiotic Prophylaxis in Pediatric Oncology 英文参考文献.docVIP

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Discrete Choice Experiment to Evaluate Factors That Influence Preferences for Antibiotic Prophylaxis in Pediatric Oncology 英文参考文献.doc

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Discrete Choice Experiment to Evaluate Factors That Influence Preferences for Antibiotic Prophylaxis in Pediatric Oncology 英文参考文献

DiscreteChoiceExperimenttoEvaluateFactorsThat InfluencePreferencesforAntibioticProphylaxisin PediatricOncology DeanA.Regier1,CarolineDiorio2,Marie-ChantalEthier2,5,AmandaAlli2,SarahAlexander3, KatherineM.Boydell4,AdamGassas3,JonathanTaylor2,CharisKellow2,DeniseMills3,LillianSung2,3* 1CanadianCentreforAppliedResearchinCancerControl,BritishColumbiaCancerResearchAgency,Vancouver,BritishColumbia,Canada, 2PrograminChildHealth Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada, 3Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada,4CommunityHealthSystemsResourceGroup,TheHospitalforSickChildren,Toronto,Ontario,Canada,5PrograminHealthResearchMethodology,McMaster University,Hamilton,Ontario,Canada Abstract Background:Bacterialandfungalinfectionsinpediatriconcologypatientscausemorbidityandmortality.Theclinicalutility ofantimicrobialprophylaxisinchildrenisuncertainandthepersonalutilityoftheseagentsisdisputed.Objectiveswereto useadiscretechoiceexperimentto:(1)describetheimportanceofattributestoparentsandhealthcareproviderswhen deciding between use and non-use of antibacterial and antifungal prophylaxis; and (2) estimate willingness-to-pay for prophylacticstrategies. Methods: Attributes were chances of infection, death and side effects, route of administration and cost of pharmacotherapy. Respondents were randomized to a discrete choice experiment outlining hypothetical treatment optionstopreventantibacterialorantifungalinfections.Eachrespondentwaspresented16choicetasksandwasaskedto choosebetweentwounlabeledtreatmentoptionsandanopt-outalternative(noprophylaxis). Results:102parentsand60healthcareprovidersparticipated.Fortheantibacterialdiscretechoiceexperiment,frequencyof administrationwassignificantlyassociatedwithutilityforparentsbutnotforhealthcareproviders.Increasingchancesof infection, death, side effects and cost were all significantly associated with decreased utility for parents and healthcare