Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response 英文参考文献.docVIP

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Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response 英文参考文献.doc

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Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response 英文参考文献

DissectionofHostCellSignalTransductionduring Acinetobacterbaumannii–TriggeredInflammatory Response CatalinaMarch1,2,Vero′nicaRegueiro1,2,EnriqueLlobet1,2,DavidMoranta1,2,PauMorey1,2 ,Junkal Garmendia1,2,3,Jose′ ABengoechea1,2,4,5 * 1Program Infection and Immunity, Fundacio′ Caubet-CIMERA Illes Balears, Bunyola, Spain, 2Area Molecular Basis of Microbial Pathogenesis, Centro de Investigacio′n Biome′dicaenRedEnfermedadesRespiratorias,Bunyola,Spain,3InstitutodeAgrobiotecnolog?′a,Pamplona,Spain,4A′readeMicrobiolog?′a,FacultadBiolog?′a,Universitat IllesBalears,PalmaMallorca,Spain,5ConsejoSuperiordeInvestigacionesCient?′ficas(CSIC),Madrid,Spain Abstract Infectedairwayepithelialcellsup-regulatetheexpressionofchemokines,chieflyIL-8,andantimicrobialmoleculesincluding b-defensins(BD).Acinetobacterbaumanniiisacauseofhospital-acquiredpneumonia.WeexaminedwhetherA.baumannii inducedtheexpressionsofIL-8andBD2byairwayepithelialcellsandthereceptorsimplicatedinbacterialdetection.A549 andhumanprimaryairwaycellsreleasedIL-8uponinfection.A.baumannii-infectedcellsalsoincreasedtheexpressionof BD2 which killed A. baummannii strains. IL-8 induction was via NF-kB and mitogen-activated kinases p38 and p44/42- dependentpathways.A.baumanniiengagedToll-likereceptor(TLR)2andTLR4pathwaysandA549cellscouldusesoluble CD14asTLRsco-receptor.A.baumanniilipopolysaccharidestimulatedIL-8releasebyA549cellsandsCD14facilitatedthe recognition of the lipopolysaccharide. Mass spectrometry analysis revealed that A. baumannii lipid A structure matches thosewithendotoxicpotential.TheseresultsdemonstratethatairwayepithelialcellsproducemediatorsimportantforA. baumanniiclearance. Citation:MarchC,RegueiroV,LlobetE,MorantaD,MoreyP,etal.(2010)DissectionofHostCellSignalTransductionduringAcinetobacterbaumannii–Triggered InflammatoryResponse.PLoSONE5(4):e10033.doi:10.1371/journal.pone.0010033 Editor:EdgardoMoreno,UniversidadNacional,CostaRica ReceivedDecember19,2009;AcceptedMarch12,2010;PublishedApril7,2010 Copyright: ? 201