DNA Barcodes Provide a Quick Preview of Mitochondrial Genome Composition 英文参考文献.docVIP

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DNA Barcodes Provide a Quick Preview of Mitochondrial Genome Composition 英文参考文献.doc

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DNA Barcodes Provide a Quick Preview of Mitochondrial Genome Composition 英文参考文献

DNABarcodesProvideaQuickPreviewofMitochondrial GenomeComposition XiangJiaMin,DonalA.Hickey* DepartmentofBiology,ConcordiaUniversity,Montreal,Quebec,Canada DNAbarcodeshaveachievedprominenceasatoolforspecies-levelidentifications.Consequently,thereisarapidlygrowing databaseoftheseshortsequencesfromawidevarietyoftaxa.Inthisstudy,wehaveanalyzedthecorrelationbetweenthe nucleotidecontentoftheshortDNAbarcodesequencesandthegenomesfromwhichtheyarederived.Ourresultsshowthat suchshortsequencescanyieldimportant,andsurprisinglyaccurate,informationaboutthecompositionoftheentiregenome. Inotherwords,forunsequencedgenomes,theDNAbarcodescanprovideaquickpreviewofthewholegenomecomposition. Citation: MinXJ,HickeyDA(2007)DNABarcodesProvideaQuickPreviewofMitochondrialGenomeComposition.PLoSONE2(3):e325.doi:10.1371/ journal.pone.0000325 INTRODUCTION RESULTSANDDISCUSSION DNAbarcodesareshort,standardizedsequencesofDNAthatare usedtoassignunknownbiologicalspecimenstoknownspecies[1– 2].Becauseoftherapidgrowthinthenumbersofthesesequences, coupled with their very broad taxonomic sampling, they could, potentially, provide insights into patterns of molecular evolution andpopulationgenetics[3]. We compiled statistics on mitochondrial genome composition basedonmorethan800completely-sequencedgenomesofanimal mitochondria (see Methods). We then compiled these same statistics for the standard DNA barcode region, comprising only 648basepairsfromthe59regionofthemitochondrialcytochrome oxidasesubunitIgene(COI)[1–2].Usingthesetwosetsofstatis- tics,weaskedhowwelltheshortDNAbarcodesequencesreflected the average properties of the genomes from which they were sampled. Here, we show that several important attributes of complete mitochondrialgenomescanbepredictedwithhighaccuracyfrom theshortbarcodesequencesalone.Theseattributesincludeaverage nucleotidecomposition,patternsofstrandasymmetry,andthehigh frequencyofcodonsthatencodehydrophobicaminoacids. ThismeansthatDNAbarcodes,orothershortsequencessampled froma wide