Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China 英文参考文献.docVIP

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Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China 英文参考文献.doc

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Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China 英文参考文献

o PL SMEDICINE DominanceofHIV-1SubtypeCRF01_AE inSexuallyAcquiredCasesLeadstoaNew EpidemicinYunnanProvinceofChina Yong Zhang1,Lin Lu1,Lei Ba2,LiLiu2,3,LiYang1,Manhong Jia1,Haibo Wang3,Qing Fang2,Yuhua Shi1,Wenyun Yan1, Guangcai Chang1,Linqi Zhang2,3,David D.Ho2,Zhiwei Chen2,3* 1YunnanCenterforDiseaseControlandPrevention,Kunming,Yunnan,People’sRepublicofChina,2AaronDiamondAIDSResearchCenter,RockefellerUniversity,New York,NewYork,UnitedStatesofAmerica,3StateKeyLaboratoryofVirology,ModernVirologyResearchCenterandAIDSCenter,WuhanUniversity,Wuhan,Hubei,People’s RepublicofChina Funding:WethankInternational AIDSVaccineInitiative,Irene DiamondFund,ChinaAIDS ABSTRACT Initiatives,andNIHgrant Background R01HL080211(toZC)fortheir support.Thefundershadnorolein studydesign,datacollectionand analysis,decisiontopublish,or preparationofthemanuscript. Datingbacktothefirstepidemicamonginjectiondrugusersin1989,theYunnanprovince has had the highest number of human immunodeficiency virus type 1 (HIV-1) infections in China. However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. MethodsandFindings AcademicEditor:ChrisBeyrer, JohnsHopkinsUniversity,United StatesofAmerica Usingimmunoassays,weidentified103,015accumulatedcasesofHIV-1infectionsinYunnan between1989and2004.Westudied321patientsrepresentingYunnan’s16prefecturesfrom four risk groups, 11 ethnic populations, and ten occupations. We identified three major circulating subtypes: C/CRF07_BC/CRF08_BC (53%), CRF01_AE (40.5%), and B (6.5%) by analyzing the sequence of p17, which is part of the gag gene. For patients with known risk factors, 90.9% of injection drug users had C/CRF07_BC/CRF08_BC viruses, whereas 85.4% of CRF01_AE infections were acquired through sexual transmission. No distinct segregation of CRF01_AE viruses was found among the Dai ethnic group. Geographically, C/CRF07_BC/ CRF08_BC was found throughout the pro