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dPORE-miRNA Polymorphic Regulation of MicroRNA Genes 英文参考文献
dPORE-miRNA:PolymorphicRegulationofMicroRNA
Genes
SebastianSchmeier,UlfSchaefer,CameronR.MacPherson,VladimirB.Bajic*
ComputationalBioscienceResearchCenter(CBRC),KingAbdullahUniversityofScienceandTechnology(KAUST),Jeddah,SaudiArabia
Abstract
Background:MicroRNAs(miRNAs)areshortnon-codingRNAmoleculesthatactaspost-transcriptionalregulatorsandaffect
theregulationofprotein-codinggenes.MostlytranscribedbyPolII,miRNAgenesareregulatedatthetranscriptionallevel
similarly to protein-coding genes. In this study we focus on human miRNAs. These miRNAs are involved in a variety of
pathwaysandcanaffectmanydiseases.OurinterestisonpossiblederegulationofthetranscriptioninitiationofthemiRNA
encodinggenes,whichisfacilitatedbyvariationsinthegenomicsequenceoftranscriptionalcontrolregions(promoters).
Methodology: Our aim is to provide an online resource to facilitate the investigation of the potential effects of single
nucleotidepolymorphisms(SNPs)onmiRNAgeneregulation.WeanalyzedSNPsoverlappedwithpredictedtranscription
factor binding sites (TFBSs) in promoters of miRNA genes. We also accounted for the creation of novel TFBSs due to
polymorphismsnotpresentinthereferencegenome.TheresultingchangesintheoriginalTFBSsandpotentialcreationof
newTFBSswereincorporatedintotheDragonDatabaseofPolymorphicRegulationofmiRNAgenes(dPORE-miRNA).
Conclusions: The dPORE-miRNA database enables researchers to explore potential effects of SNPs on the regulation of
miRNAs. dPORE-miRNA can be interrogated with regards to: a/miRNAs (their targets, or involvement in diseases, or
biological pathways), b/SNPs, or c/transcription factors. dPORE-miRNA can be accessed at .sa/
dporeandhttp://apps.sanbi.ac.za/dpore/.Itsuseisfreeforacademicandnon-profitusers.
Citation: Schmeier S, Schaefer U, MacPherson CR, Bajic VB (2011) dPORE-miRNA: Polymorphic Regulation of MicroRNA Genes. PLoS ONE 6(2): e16657.
doi:10.1371/journal.pone.0016657
Editor:ChristosOuzounis,TheCentreforResearchandTechnology,Greece
ReceivedSeptember6,2010;Acc
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