Does α +-Thalassaemia Protect against Malaria 英文参考文献.docVIP

respPectives eosD α -Thalassaemia Protect against + Malaria? A new study ?nds that α Geoffrey Pasvol + -thalassaemia protects against severe but not mild malaria E ver since Haldane proposed in 1949 that thalassaemia might protect individuals against the scourge of malaria [1], the challenge has been to provide supporting thalassaemia (in which one or two of the four α-globin genes are deleted) is exceedingly common throughout sub-Saharan Africa, an area of high malarial transmission. However, thus polymorphisms may be intellectually attractive, some would argue that it is of little clinical relevance. A New Study on α -Thalassaemia + evidence—be it at the cellular, clinical, or epidemiological level. The general topic of human red cell polymorphisms and malarial protection has attracted enormous interest, largely because this subject provides the most compelling example of natural selection and, hence, “survival of the ?ttest” in humans. Sickle cell trait remains the paradigm of a red cell polymorphism that protects against malaria. Several lines of evidence, including plausible cellular mechanisms, con?rm that this haemoglobinopathy provides up to 90% protection against death due to malaria [2]. However, there are many gaps in our knowledge of whether other common red cell variants, far, the effects of α + -thalassaemia on Notwithstanding this, Sammy Wambua, Thomas Williams, and colleagues, [9] in a new study in PLoS Medicine, have now cogently approached + the conundrum of α -thalassaemia and malaria in a structured and the clinical manifestations of malaria in this area have not been extensively studied. And the few studies that have been carried out on the relationship between α + -thalassaemia and malaria have not provided an all-encompassing and plausible cellular mechanism for protection. compelling fashion within an area of intensive malarial transmission in sub-Saharan Africa. They studied two cohorts of children: (1) a cohort with “mild disease”, re