Dynamic Effective Connectivity of Inter-Areal Brain Circuits 英文参考文献.docVIP

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Dynamic Effective Connectivity of Inter-Areal Brain Circuits 英文参考文献.doc

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Dynamic Effective Connectivity of Inter-Areal Brain Circuits 英文参考文献

DynamicEffectiveConnectivityofInter-ArealBrain Circuits DemianBattaglia1,2*,AnnetteWitt1,2,3,FredWolf1,2,TheoGeisel1,2 1MaxPlanckInstituteforDynamicsandSelf-Organization,Go¨ttingen,Germany,2BernsteinCenterforComputationalNeuroscience,Go¨ttingen,Germany,3Cognitive NeuroscienceLaboratory,GermanPrimateCenter,Go¨ttingen,Germany Abstract Anatomicconnectionsbetweenbrainareasaffectinformationflowbetweenneuronalcircuitsandthesynchronizationof neuronalactivity.However,suchstructuralconnectivitydoesnotcoincidewitheffectiveconnectivity(or,moreprecisely, causal connectivity), related to the elusive question ‘‘Which areas cause the present activity of which others?’’. Effective connectivityisdirectedanddependsflexiblyoncontextsandtasks.Hereweshowthatdynamiceffectiveconnectivitycan emergefromtransitionsinthecollectiveorganizationofcoherentneuralactivity.Integratingsimulationandsemi-analytic approaches,westudymesoscalenetworkmotifsofinteractingcorticalareas,modeledaslargerandomnetworksofspiking neuronsorassimplerateunits.Throughacausalanalysisoftime-seriesofmodelneuralactivity,weshowthatdifferent dynamical states generated by a same structural connectivity motif correspond to distinct effective connectivity motifs. Such effective motifs can display a dominant directionality, due to spontaneous symmetry breaking and effective entrainmentbetweenlocalbrainrhythms,althoughallconnectionsintheconsideredstructuralmotifsarereciprocal.We showthenthattransitionsbetweeneffectiveconnectivityconfigurations(like,forinstance,reversalinthedirectionofinter- arealinteractions)canbetriggeredreliablybybriefperturbationinputs,properlytimedwithrespecttoanongoinglocal oscillation, without the need for plastic synaptic changes. Finally, we analyze how the information encoded in spiking patterns of a local neuronal population is propagated across a fixed structural connectivity motif, demonstrating that changes in the active effective connectivity regulate both the efficiency and the directionality of i