Dysfunctions Associated with Methylation, MicroRNA Expression and Gene Expression in Lung Cancer 英文参考文献.docVIP

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Dysfunctions Associated with Methylation, MicroRNA Expression and Gene Expression in Lung Cancer 英文参考文献.doc

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Dysfunctions Associated with Methylation, MicroRNA Expression and Gene Expression in Lung Cancer 英文参考文献

DysfunctionsAssociatedwithMethylation,MicroRNA ExpressionandGeneExpressioninLungCancer TaoHuang2,3¤,MinJiang4,5,XiangyinKong4,5*,Yu-DongCai1* 1InstituteofSystemsBiology,ShanghaiUniversity,Shanghai,People’sRepublicofChina,2KeyLaboratoryofSystemsBiology,ShanghaiInstitutesforBiologicalSciences, ChineseAcademyofSciences,Shanghai,People’sRepublicofChina,3ShanghaiCenterforBioinformationTechnology,Shanghai,People’sRepublicofChina,4Instituteof Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, People’s RepublicofChina,5StateKeyLaboratoryofMedicalGenomics,RuijinHospital,ShanghaiJiaotongUniversity,Shanghai,People’sRepublicofChina Abstract Integratinghigh-throughputdataobtainedfromdifferentmolecularlevelsisessentialforunderstandingthemechanismsof complexdiseasessuchascancer.Inthisstudy,weintegratedthemethylation,microRNAandmRNAdatafromlungcancer tissuesandnormallungtissuesusingfunctionalgenesets.ForeachGeneOntology(GO)term,threesetsweredefined:the methylationset,themicroRNAsetandthemRNAset.Thediscriminatingabilityofeachgenesetwasrepresentedbythe Matthews correlation coefficient (MCC), as evaluated by leave-one-out cross-validation (LOOCV). Next, the MCCs in the methylation sets, the microRNA sets and the mRNA sets were ranked. By comparing the MCC ranks of methylation, microRNA and mRNA for each GO term, we classified the GO sets into six groups and identified the dysfunctional methylation, microRNA and mRNA gene sets in lung cancer. Our results provide a systematic view of the functional alterations during tumorigenesis that may help to elucidate the mechanisms of lung cancer and lead to improved treatmentsforpatients. Citation:HuangT,JiangM,KongX,CaiY-D(2012)DysfunctionsAssociatedwithMethylation,MicroRNAExpressionandGeneExpressioninLungCancer.PLoS ONE7(8):e43441.doi:10.1371/journal.pone.0043441 Editor:DaotaiNie,SouthernIllinoisUniversitySchoolofMedicine,UnitedStatesofAmer