Dynamic Changes of Lipopolysaccharide Levels in Different Phases of Acute on Chronic Hepatitis B Liver Failure 英文参考文献.docVIP

下载本文档

3
0
约3.44万字
约 7页
2017-05-11 发布于上海
举报
版权申诉

Dynamic Changes of Lipopolysaccharide Levels in Different Phases of Acute on Chronic Hepatitis B Liver Failure 英文参考文献.doc

1、本文档共7页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Dynamic Changes of Lipopolysaccharide Levels in Different Phases of Acute on Chronic Hepatitis B Liver Failure 英文参考文献

DynamicChangesofLipopolysaccharideLevelsin DifferentPhasesofAcuteonChronicHepatitisBLiver Failure CalvinPan1.,YurongGu2.,WeiZhang3,YubaoZheng2,LiangPeng2,HongDeng2,YoumingChen2, LubiaoChen2,SuiChen2,MinZhang2,ZhiliangGao2* 1DivisionofLiverDiseases,DepartmentofMedicine,TheMountSinaiMedicalCenter,MountSinaiSchoolofMedicine,NewYork,NewYork,UnitedStatesofAmerica, 2Department of Infectious Disease, The Third Affiliated, Hospital of Sun-Yet-Sen University, Guangzhou, China, 3Department of Infectious Disease, Beijing Youan Hospital,CapitalMedicalUniversity,Beijing,China Abstract Background: High serum levels of lipopolysaccharide (LPS) with LPS-MD-2/TLR4 complex activated NF-kb and cytokine cause hepatic necrosis in animal models. We investigated the dynamic changes of LPS levels in patients with acute on chronichepatitisBliverfailure(ACHBLF). Methods: We enrolled ACHBLF patients for a 12-week study. Patients’ LPS levels were measured along with 10 healthy controls.Patientsonsupportivecareandrecoveredwithoutintervention(s)wereanalyzed.Patients’LPSlevelsduringthe diseaseprogressionphase,peakphase,andremissionphasewerecomparedwithhealthycontrols. Results:Among30patientsenrolled,25whoreceivedinterventionsorexpiredduringthestudyperiodwereexcludedfrom theanalysis,fivepatientsonsupportivecarewhocompletedthestudywereanalyzed.Significantabnormaldistributionsof LPS levels were observed in patients in different phases (0.016860.0101 in progression phase; 0.096060.0680 in peak phase;0.024960.0365inremissionphase;and0.020160.0146incontrols;respectively,p,0.05).ThehighestlevelofLPS wasinthepeakphaseandsignificantlyelevatedwhencomparedtocontrols(0.020160.0146vs.0.096060.0680,p=0.007). There were no statistically significant differences in LPS levels between healthy controls and subjects in the progression phase or remission phase. Dynamic changes of LPS were correlated with MELD-Na in the progression phase (p=0.01, R=0.876)andinthepeakphase(p=0.000,R=21.00). Conclusions:Significantabn