Dynamic Contrast-Enhanced MRI Assessment of Hyperemic Fractional Microvascular Blood Plasma Volume in Peripheral Arterial Disease Initial Findings 英文参考文献.docVIP

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Dynamic Contrast-Enhanced MRI Assessment of Hyperemic Fractional Microvascular Blood Plasma Volume in Peripheral Arterial Disease Initial Findings 英文参考文献.doc

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Dynamic Contrast-Enhanced MRI Assessment of Hyperemic Fractional Microvascular Blood Plasma Volume in Peripheral Arterial Disease Initial Findings 英文参考文献

DynamicContrast-EnhancedMRIAssessmentof HyperemicFractionalMicrovascularBloodPlasma VolumeinPeripheralArterialDisease:InitialFindings BasVersluis1,4,MarjoleinH.G.Dremmen1,PattyJ.Nelemans3,JoachimE.Wildberger1,4 ,Geert- WillemSchurink2,TimLeiner1,4,WalterH.Backes1,4 * 1DepartmentofRadiology,MaastrichtUniversityMedicalCenter(MUMC+),Maastricht,TheNetherlands,2DepartmentofSurgery,MaastrichtUniversityMedicalCenter (MUMC+), Maastricht, The Netherlands, 3Department of Epidemiology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands, 4Cardiovascular ResearchInstituteMaastricht(CARIM),Maastricht,TheNetherlands Abstract Objectives:Theaimofthecurrentstudywastodescribeamethodthatassessesthehyperemicmicrovascularbloodplasma volumeofthecalfmusculature.Thereversiblyalbuminbindingcontrastagentgadofosvesetwasusedindynamiccontrast- enhanced magnetic resonance imaging (DCE MRI) to assess the microvascular status in patients with peripheral arterial disease(PAD)andhealthycontrols.Inaddition,thereproducibilityofthismethodinhealthycontrolswasdetermined. MaterialsandMethods:TenPADpatientswithintermittentclaudicationand10healthycontrolsubjectswereincluded. Patientsunderwentcontrast-enhancedMRangiographyoftheperipheralarteries,followedbyoneDCEMRIexaminationof themusculatureofthecalf.Healthycontrolsubjectswereexaminedtwiceondifferentdaystodeterminenormativevalues and the interreader and interscan reproducibility of the technique. The MRI protocol comprised dynamic imaging of contrastagentwash-inunderreactivehyperemiaconditionsofthecalfmusculature.Usingpharmacokineticmodelingthe hyperemic fractional microvascular blood plasma volume (Vp, unit: %) of the anterior tibial, gastrocnemius and soleus muscleswascalculated. Results:VpwassignificantlylowerforallmusclegroupsinPADpatients(4.361.6%,5.063.3%and6.163.6%foranterior tibial, gastrocnemius and soleus muscles, respectively) compared to healthy control subjects (9.162.0%, 8.961.9% and 9.362.1%).DifferencesinVpbetweenmusc