Effects of Exogenous Cholecystokinin Octapeptide on Acquisition of Naloxone Precipitated Withdrawal Induced Conditioned Place Aversion in Rats 英文参考文献.docVIP

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Effects of Exogenous Cholecystokinin Octapeptide on Acquisition of Naloxone Precipitated Withdrawal Induced Conditioned Place Aversion in Rats 英文参考文献.doc

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Effects of Exogenous Cholecystokinin Octapeptide on Acquisition of Naloxone Precipitated Withdrawal Induced Conditioned Place Aversion in Rats 英文参考文献

EffectsofExogenousCholecystokininOctapeptideon AcquisitionofNaloxonePrecipitatedWithdrawal InducedConditionedPlaceAversioninRats HaileiYu.,DiWen.,ChunlingMa*,YanxinMeng,ShujinLi,ZhiyuNi,BinCong* DepartmentofForensicMedicine,HebeiMedicalUniversity,HebeiKeyLaboratoryofForensicMedicine,Shijiazhuang,People’sRepublicofChina Abstract Cholecystokinin octapeptide (CCK-8), a gut-brain peptide, regulates a variety of physiological behavioral processes. Previously, we reported that exogenous CCK-8 attenuated morphine-induced conditioned place preference, but the possibleeffectsofCCK-8onaversivelymotivateddrugseekingremainedunclear.Toinvestigatetheeffectsofendogenous and exogenous CCK on negative components of morphine withdrawal, we evaluated the effects of CCK receptor antagonists and CCK-8 on the naloxone-precipitated withdrawal-induced conditioned place aversion (CPA). The results showedthatCCK2receptorantagonist(LY-288,513,10mg,i.c.v.),butnotCCK1receptorantagonist(L-364,718,10mg,i.c.v.), inhibited the acquisition of CPA when given prior to naloxone (0.3mg/kg) administration in morphine-dependent rats. Similarly,CCK-8(0.1–1mg,i.c.v.)significantlyattenuatednaloxone-precipitatedwithdrawal-inducedCPA,andthisinhibitory functionwasblockedbyco-injectionwithL-364,718.MicroinjectionofL-364,718,LY-288,513orCCK-8tosalinepretreated rats produced neither a conditioned preference nor aversion, and the induction of CPA by CCK-8 itself after morphine pretreatments wasnotsignificant. Our studyidentifies adifferentrole of CCK1and CCK2receptors innegativeaffective componentsof morphineabstinenceandaninhibitory effectofexogenous CCK-8onnaloxone-precipitated withdrawal- inducedCPAviaCCK1receptor. Citation:YuH,WenD,MaC,MengY,LiS,etal.(2012)EffectsofExogenousCholecystokininOctapeptideonAcquisitionofNaloxonePrecipitatedWithdrawal InducedConditionedPlaceAversioninRats.PLoSONE7(7):e41860.doi:10.1371/journal.pone.0041860 Editor:Franc?ois Blachier,NationalInstituteofAgronomicResearch,France Re