Elastic Energy Storage and Radial Forces in the Myofilament Lattice Depend on Sarcomere Length 英文参考文献.docVIP

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Elastic Energy Storage and Radial Forces in the Myofilament Lattice Depend on Sarcomere Length 英文参考文献.doc

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Elastic Energy Storage and Radial Forces in the Myofilament Lattice Depend on Sarcomere Length 英文参考文献

ElasticEnergyStorageandRadialForcesinthe MyofilamentLatticeDependonSarcomereLength C.DavidWilliams1*,MichaelRegnier1,2,ThomasL.Daniel2,3 1Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America, 2Department of Bioengineering, University of Washington,Seattle,Washington,UnitedStatesofAmerica,3DepartmentofBiology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Abstract Wemostoftenconsidermuscleasamotorgeneratingforceinthedirectionofshortening,butlessoftenconsideritsroles asaspringorabrake.Herewedevelopafullythree-dimensionalspatiallyexplicitmodelofmuscletoisolatethelocationsof forcesandenergiesthataredifficulttoseparateexperimentally.Weshowthestrainenergyinthethickandthinfilamentsis lessthanonethirdthestrainenergyinattachedcross-bridges.Thisresultsuggeststhecross-bridgesactassprings,storing energy within muscle in addition to generating the force which powers muscle. Comparing model estimates of energy consumedtoelasticenergystored,weshowthattheratioofthesetwopropertieschanges withsarcomere length.The modelpredictsstorageofagreaterfractionofenergyatshortsarcomerelengths,suggestingamechanismbywhichmuscle function shifts as force production declines, from motor to spring. Additionally, we investigate the force that muscle produces in the radial or transverse direction, orthogonal to the direction of shortening. We confirm prior experimental estimatesthatplaceradialforcesonthesameorderofmagnitudeasaxialforces,althoughwefindthatradialforcesand axialforcesvarydifferentlywithchangesinsarcomerelength. Citation: Williams CD, Regnier M, Daniel TL (2012) Elastic Energy Storage and Radial Forces in the Myofilament Lattice Depend on Sarcomere Length. PLoS ComputBiol8(11):e1002770.doi:10.1371/journal.pcbi.1002770 Editor:AndrewD.McCulloch,UniversityofCaliforniaSanDiego,UnitedStatesofAmerica ReceivedJune19,2012;AcceptedSeptember19,2012;PublishedNovember15,2012 Copyright: ? 2012 Williams et al. This is a